{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:02:02Z","timestamp":1791910922075,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Profound Medical Inc."}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report the 3\u2010year follow\u2010up of a Phase I study of magnetic resonance imaging (MRI)\u2010guided transurethral ultrasound ablation (TULSA) in 30 men with localised prostate cancer. Favourable 12\u2010month safety and ablation precision were previously described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>As a mandated safety criterion, TULSA was delivered as near whole\u2010gland ablation, applying 3\u2010mm margins sparing 10% of peripheral prostate tissue in 30 men. After 12\u2010month biopsy and MRI, biannual follow\u2010up included prostate\u2010specific antigen (PSA), adverse events (AEs), and functional quality\u2010of\u2010life assessment, with repeat systematic biopsy at 3\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A 3\u2010year follow\u2010up was completed by 22 patients. Between 1 and 3\u00a0years, there were no new serious or severe AEs. Urinary and bowel function remained stable. Erectile function recovered by 1\u00a0year and was stable at 3\u00a0years. The PSA level decreased 95% to a median (interquartile range) nadir of 0.33\u00a0(0.1\u20130.4) ng\/mL, stable to 0.8\u00a0(0.4\u20131.6)\u00a0ng\/mL at 3\u00a0years. Serial biopsies identified clinically significant disease in 10\/29 men (34%) and any cancer in 17\/29 (59%). By 3\u00a0years, seven men had recurrence (four histological, three biochemical) and had undergone salvage therapy without complications (including six prostatectomies). At 3\u00a0years, three of 22 men refused biopsy, and two of the 22 (9%) had clinically significant disease (one new, one persistent). Predictors of salvage therapy requirement included less extensive ablation coverage and higher PSA nadir.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>With 3\u2010year Phase I follow\u2010up, TULSA demonstrates safe and precise ablation for men with localised prostate cancer, providing predictable PSA and biopsy outcomes, without affecting functional abilities or precluding salvage therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15268","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T12:28:17Z","timestamp":1607084897000},"page":"544-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Magnetic resonance imaging\u2010guided transurethral ultrasound ablation in patients with localised prostate cancer: 3\u2010year outcomes of a prospective Phase I study"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1075-3730","authenticated-orcid":false,"given":"Shiva M.","family":"Nair","sequence":"first","affiliation":[{"name":"London Health Sciences Centre Western University London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0913-8420","authenticated-orcid":false,"given":"Gencay","family":"Hatiboglu","sequence":"additional","affiliation":[{"name":"German Cancer Research Center University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Relle","sequence":"additional","affiliation":[{"name":"Beaumont Health System Royal Oak MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Hetou","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre Western University London ON 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