{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:25:05Z","timestamp":1780723505951,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the predictive value of tumour\u2010infiltrating immune cells (TIICs) on oncological outcomes and response to BCG treatment in patients with non\u2010muscle\u2010invasive bladder cancer (NMIBC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis was performed using PubMed, Scopus and the Cochrane Library in July 2020 to identify relevant studies according to the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) statement. The pooled recurrence\u2010free survival (RFS) rate was calculated using a fixed\u2010effect model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We retrieved 15 studies (including 791 patients) evaluating the effect of TIICs on oncological outcomes in patients with NMIBC treated with intravesical BCG. TIICs were reported to be a significant predictor of oncological outcomes and response to BCG treatment in 10 studies. Tumour\u2010associated macrophages were associated with worse RFS (pooled hazard ratio 2.30, 95% confidence interval 1.64\u20133.22).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on these data, TIICs are significant predictors of RFS and response to BCG treatment in patients with NMIBC; therefore, incorporation of TIICs into risk stratification models may help patients and physicians in the clinical decision\u2010making process in order to achieve the maximum possible benefit from BCG treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15276","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T12:04:57Z","timestamp":1607083497000},"page":"617-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Value of tumour\u2010infiltrating immune cells in predicting response to intravesical BCG in patients with non\u2010muscle\u2010invasive bladder cancer: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9380-8492","authenticated-orcid":false,"given":"Mehdi","family":"Kardoust Parizi","sequence":"first","affiliation":[{"name":"Department of Urology Shariati Hospital Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Urology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6627-6179","authenticated-orcid":false,"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Vienna Vienna Austria"},{"name":"Department of Urology University of Texas Southwestern Medical Center Dallas TX USA"},{"name":"Department of Urology Weill Cornell Medical College New York NY USA"},{"name":"Department of Urology Second Faculty of Medicine Charles University Prag Czech Republic"},{"name":"Institute for Urology and Reproductive Health I.M. Sechenov First Moscow State Medical University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5837-4561","authenticated-orcid":false,"given":"Vitaly","family":"Margulis","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-6569","authenticated-orcid":false,"given":"Keiichiro","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Vienna Vienna Austria"},{"name":"Department of Urology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5692-2723","authenticated-orcid":false,"given":"Yair","family":"Lotan","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.07.033"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2018.11.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.06.045"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.10.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.4070"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.05.033"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.01.040"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2013.06.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_8_11_1","article-title":"Evaluating non\u2010randomised intervention studies","author":"Deeks JJ","journal-title":"Health Technol Assess (Winchester, England)"},{"key":"e_1_2_8_12_1","unstructured":"HigginsJPT GreenS.Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. 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