{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:21:05Z","timestamp":1793467265853,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To present an overall picture of the evidence regarding the association of erectile dysfunction (ED) with cardiovascular disease (CVD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Systematic reviews and meta\u2010analyses that studied the association of ED with any CVD were included in this umbrella review. We did not restrict the population to a particular group or age. PubMed, Embase, the Joanna Briggs Institute (JBI) Database of Systematic Reviews and Implementation Reports, the Cochrane Database of Systematic Reviews, the Database of Abstracts of Reviews of Effects, and the PROSPERO register were searched to find relevant systematic reviews, with or without meta\u2010analyses, from inception to April 2020. The JBI Checklist for Systematic Reviews and Research Syntheses was used for the critical appraisal. Only studies with acceptable quality were included. Two independent reviewers extracted the data using the JBI data extraction tool for qualitative and quantitative data extraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The summary estimate showed a higher risk of CVD (relative risk [RR] 1.45, 95% confidence interval [CI] 1.36\u20131.54;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), coronary heart disease (RR 1.50, 95% CI 1.37\u20131.64;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), cardiovascular\u2010related mortality (RR 1.50, 95% CI 1.37\u20131.64;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), all\u2010cause mortality (RR 1.25, 95% CI 1.18\u20131.32;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), myocardial infarction (RR 1.55, 95% CI 1.33\u20131.80;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) and stroke (RR 1.36, 95% CI 1.26\u20131.46;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) in patients with ED than in other patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results confirm that ED is an independent predictor of CVD and their outcomes. ED and CVD are two presentations of the same physiological phenomenon. ED normally precedes symptomatic CVD, providing a window of opportunity for healthcare practitioners to screen and detect high\u2010risk patients early to prevent avoidable morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15313","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T12:20:21Z","timestamp":1607084421000},"page":"3-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Association of erectile dysfunction and cardiovascular disease: an umbrella review of systematic reviews and meta\u2010analyses"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5596-1771","authenticated-orcid":false,"given":"Hadi","family":"Mostafaei","sequence":"first","affiliation":[{"name":"Department of Urology Comprehensive Cancer Centre Medical University of Vienna Vienna Austria"},{"name":"Research Centre for Evidence\u2010Based Medicine Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-6569","authenticated-orcid":false,"given":"Keiichiro","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Urology Comprehensive Cancer Centre Medical University of Vienna Vienna Austria"},{"name":"Department of Urology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1494-7097","authenticated-orcid":false,"given":"Sakineh","family":"Hajebrahimi","sequence":"additional","affiliation":[{"name":"Research Centre for Evidence\u2010Based Medicine Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6603-6319","authenticated-orcid":false,"given":"Mohammad","family":"Abufaraj","sequence":"additional","affiliation":[{"name":"Department of Urology Comprehensive Cancer Centre Medical University of Vienna Vienna Austria"},{"name":"Division of Urology Department of Special Surgery Jordan University Hospital University of Jordan Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre I.","family":"Karakiewicz","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit Division of Urology University of Montreal Health Center Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology Comprehensive Cancer Centre Medical University of Vienna Vienna Austria"},{"name":"Institute for Urology and Reproductive Health I.M. 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