{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:42:10Z","timestamp":1761766930399,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To review the utility of vesicourethral anastomosis (VUA)\u2010directed biopsy in the setting of biochemical recurrence (BCR) after radical prostatectomy (RP) for prostate cancer (PCa) in patients who have undergone evaluation by gallium\u201068 prostate\u2010specific membrane antigen positron emission tomography with computed tomography (\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010PSMA PET\/CT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We completed a retrospective review of a prospectively maintained dataset from January 2015 to August 2020. Patient demographics were recorded for those who experienced BCR, as defined by a rise in prostate\u2010specific antigen (PSA) level to above 0.2 ng\/mL, who had a\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010PSMA PET\/CT that did not demonstrate recurrence within the prostate bed, and who subsequently underwent a transperineal ultrasonography (TPUS)\u2010guided biopsy directed at the VUA. Histological reporting of the biopsies was undertaken in order to determine whether the benefits of salvage radiation therapy (SRT) could be justified by the presence of cancer cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighteen patients who had a\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010PSMA PET\/CT and underwent VUA\u2010directed biopsy were identified as having BCR.\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010PSMA PET\/CT scans demonstrated avidity at the VUA in none of the patients, although two out of 18 patients showed avidity in the seminal vesicles and two out of 18 patients showed avidity within regional lymph nodes. Histology from the TPUS\u2010guided, VUA\u2010directed biopsies demonstrated no prostatic tissue in six out of 18 and presence of prostatic tissue in 12 out of 18 of patients, respectively. In 7 out of 18 cases, there was histological evidence of recurrent PCa at the VUA in the absence of a positive\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010PSMA PET\/CT scan.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study highlights the potential value of VUA\u2010directed biopsy. We are reminded that a negative\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010PSMA PET\/CT does not exclude local recurrence and that the addition of a VUA\u2010directed biopsy may aid in the decision\u2010making process for patients with BCR following RP, especially when\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010PSMA PET\/CT is locally negative. When the result of both\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010PSMA PET\/CT and VUA\u2010directed biopsy are negative, it should encourage clinicians to share decision\u2010making in regard to undertaking SRT vs continuing BCR surveillance. This may delay the possible side effects associated with SRT, despite its excellent PSA failure\u2010free survival rate.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15315","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T02:56:02Z","timestamp":1620701762000},"page":"23-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vesico\u2010urethral anastomosis sampling: a forgotten tool for guiding salvage radiation after radical prostatectomy"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6195-3364","authenticated-orcid":false,"given":"Brennan","family":"Timm","sequence":"first","affiliation":[{"name":"Department of Urology Austin Health Heidelberg, Vic., Australia"},{"name":"North Eastern Urology Heidelberg, Vic., Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3306-1531","authenticated-orcid":false,"given":"Matthew","family":"Farag","sequence":"additional","affiliation":[{"name":"Department of Urology Austin Health Heidelberg, Vic., Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Liodakis","sequence":"additional","affiliation":[{"name":"Department of Urology Austin Health Heidelberg, Vic., Australia"},{"name":"North Eastern Urology Heidelberg, Vic., Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Angus","sequence":"additional","affiliation":[{"name":"Department of Urology Austin Health Heidelberg, Vic., Australia"},{"name":"North Eastern Urology Heidelberg, Vic., Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daryl","family":"Lim Joon","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Austin Health Heidelberg Vic Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5145-6783","authenticated-orcid":false,"given":"Damien","family":"Bolton","sequence":"additional","affiliation":[{"name":"Department of Urology Austin Health Heidelberg, Vic., Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15129"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14773"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","unstructured":"MoroteJ ComasI PlanasJRe: Nicolas Mottet Joaquim Bellmunt Erik Brierset al.EAU\u2010ESTRO\u2010ESUR\u2010SIOG Guidelines on Prostate Cancer. European Association of Urology; 2017. http:\/\/uroweb.org\/guideline\/prostate\u2010cancer: How to Assess the Efficacy of Medical Castration.Eur Urol. 2018;73:e134\u2010e5.","DOI":"10.1016\/j.eururo.2018.01.039"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2525-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.160382"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14794"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.06.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.4853"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13397"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14886"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.01.049"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2018.09.010"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)00351-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001070"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2014.0242"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.196683"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.235028"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2020.01.003"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.4111\/icu.2019.60.1.54"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12536"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15124"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-020-10043-1"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2017.08.031"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.15315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bju.15315","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.15315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:38:53Z","timestamp":1761748733000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.15315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":24,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/bju.15315"],"URL":"https:\/\/doi.org\/10.1111\/bju.15315","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"type":"print","value":"1464-4096"},{"type":"electronic","value":"1464-410X"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"2020-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}