{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:32:35Z","timestamp":1791203555588,"version":"4.2.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the feasibility of local anaesthetic transperineal (LATP) technique using a single\u2010freehand transperineal (TP) access device, and report initial prostate cancer (PCa) detection, infection rates, and tolerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Observational study of a multicentre prospective cohort, including all consecutive cases. LATP was performed in three settings: (i) first biopsy in suspected PCa, (ii) confirmatory biopsies for active surveillance, and (iii) repeat biopsy in suspected PCa. All patients received pre\u2010procedure antibiotics according to local hospital guidelines. Local anaesthesia was achieved by perineal skin infiltration and periprostatic nerve block without sedation. Ginsburg protocol principles were followed for systematic biopsies including cognitive magnetic resonance imaging\u2010targeted biopsies when needed using the PrecisionPoint\u2122 TP access device. Procedure\u2010related complications and oncological outcomes were prospectively and consecutively collected. A validated questionnaire was used in a subset of centres to collect data on patient\u2010reported outcome measures (PROMs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Some 1218 patients underwent LATP biopsies at 10 centres: 55%, 24%, and 21% for each of the three settings, respectively. Any grade PCa was diagnosed in 816 patients (67%), of which 634 (52% of total) had clinically significant disease. Two cases of sepsis were documented (0.16%) and urinary retention was observed in 19 patients (1.6%). PROMs were distributed to 419 patients, with a 56% response rate (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0234). In these men, pain during the biopsy was described as either \u2018not at all\u2019 or \u2018a little\u2019 painful by 64% of patients. Haematuria was the most common reported symptom (77%). When exploring attitude to re\u2010biopsy, 48% said it would be \u2018not a problem\u2019 and in contrast 8.1% would consider it a \u2018major problem\u2019. Most of the patients (81%) described the biopsy as a \u2018minor or moderate procedure tolerable under local anaesthesia\u2019, while 5.6% perceived it as a \u2018major procedure that requires general anaesthesia\u2019.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data suggest that LATP biopsy using a TP access system mounted to the ultrasound probe achieves excellent PCa detection, with a very low sepsis rate, and is safe and well tolerated. We believe a randomised controlled trial comparing LATP with transrectal ultrasound\u2010guided biopsy (TRUS) to investigate the relative trade\u2010offs between each biopsy technique would be helpful.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15337","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T18:29:34Z","timestamp":1610735374000},"page":"311-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Local anaesthetic transperineal (LATP) prostate biopsy using a probe\u2010mounted transperineal access system: a multicentre prospective outcome analysis"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6498-2635","authenticated-orcid":false,"given":"J. 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