{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:36:14Z","timestamp":1789580174762,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006044","name":"Astellas Pharma Europe","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100006044","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the impact of using clinical stage assessed by multiparametric magnetic resonance imaging (mpMRI) on the performance of two established nomograms for the prediction of pelvic lymph node involvement (LNI) in patients with prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Patients undergoing robot\u2010assisted extended pelvic lymph node dissection (ePLND) from 2015 to 2019 at three teaching hospitals were retrospectively evaluated. Risk of LNI was calculated four times for each patient, using clinical tumour stage (T\u2010stage) assessed by digital rectal examination (DRE) and by mpMRI, in the Memorial Sloan Kettering Cancer Centre (MSKCC; 2018) and Briganti (2012) nomograms. Discrimination (area under the curve [AUC]), calibration, and the net benefit of these four strategies were assessed and compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1062 patients were included, of whom 301 (28%) had histologically proven LNI. Using DRE T\u2010stage resulted in AUCs of 0.71 (95% confidence interval [CI] 0.70\u20130.72) for the MSKCC and 0.73 (95% CI 0.72\u20130.74) for the Briganti nomogram. Using mpMRI T\u2010stage, the AUCs were 0.72 (95% CI 0.71\u20130.73) for the MSKCC and 0.75 (95% CI 0.74\u20130.76) for the Briganti nomogram. mpMRI T\u2010stage resulted in equivalent calibration compared with DRE T\u2010stage. Combined use of mpMRI T\u2010stage and the Briganti 2012 nomogram was shown to be superior in terms of AUC, calibration, and net benefit. Use of mpMRI T\u2010stage led to increased sensitivity for the detection of LNI for all risk thresholds in both models, countered by a decreased specificity, compared with DRE T\u2010stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>T\u2010stage as assessed by mpMRI is an appropriate alternative for T\u2010stage assessed by DRE to determine nomogram\u2010based risk of LNI in patients with prostate cancer, and was associated with improved model performance of both the MSKCC 2018 and Briganti 2012 nomograms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15376","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T09:36:45Z","timestamp":1614245805000},"page":"236-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["External validation of the Memorial Sloan Kettering Cancer Centre and Briganti nomograms for the prediction of lymph node involvement of prostate cancer using clinical stage assessed by magnetic resonance imaging"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0259-8750","authenticated-orcid":false,"given":"Timo F.W.","family":"Soeterik","sequence":"first","affiliation":[{"name":"Department of Value\u2010Based Healthcare Santeon Utrecht The Netherlands"},{"name":"Department of Urology St. Antonius Hospital Nieuwegein\/Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom A.","family":"Hueting","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Services Research Technical Medical Centre University of Twente Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4848-4537","authenticated-orcid":false,"given":"Bas","family":"Israel","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"},{"name":"Department of Urology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm H.E.","family":"van Melick","sequence":"additional","affiliation":[{"name":"Department of Urology St. Antonius Hospital Nieuwegein\/Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea M.","family":"Dijksman","sequence":"additional","affiliation":[{"name":"Department of Value\u2010Based Healthcare Santeon Utrecht The Netherlands"},{"name":"Department of Value\u2010Based Healthcare St. Antonius Hospital Nieuwegein\/Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Stomps","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Group Twente Hengelo\/Almelo The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douwe H.","family":"Biesma","sequence":"additional","affiliation":[{"name":"Department of Value\u2010Based Healthcare Santeon Utrecht The Netherlands"},{"name":"Department of Value\u2010Based Healthcare St. Antonius Hospital Nieuwegein\/Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Koffijberg","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Services Research Technical Medical Centre University of Twente Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Sedelaar","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alfred","family":"Witjes","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul A.","family":"van Basten","sequence":"additional","affiliation":[{"name":"Department of Urology Canisius Wilhelmina Hospital Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,16]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"MottetN van denBerghRCN BriersEet\u00a0al.EAU \u2013 ESTRO \u2013 ESUR \u2013 SIOG Guidelines on Prostate Cancer 2019; presented at the EAU Annual Congress Barcelona 2019. Arnhem The Netherlands: European Association of Urology Guidelines Office"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.05.034"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14944"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.01.049"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.12.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15220"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0060"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2018.04.016"},{"key":"e_1_2_7_10_1","unstructured":"Memorial Sloan Kettering Cancer Center.Pre\u2010radical prostatectomy tool to predict probability of lymph node involvement in prostate cancer patients. Available at:www.mskcc.org\/nomograms\/prostate\/pre_op. Accessed June 15 2020"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.10.044"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000617"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.07.029"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.06.046"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.08.052"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.07.035"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.160"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0698"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2020.01.028"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X06295361"},{"key":"e_1_2_7_22_1","first-page":"1","article-title":"Multivariate imputation by chained equations in R","volume":"45","author":"Van Buuren S","year":"2011","journal-title":"J Stat Soft"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-017-0026-5"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-019-0164-z"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.10.012"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000652"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.03.023"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.12.018"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2020.08.089"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/1078-1439(95)00066-6"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.15376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bju.15376","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.15376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T15:40:54Z","timestamp":1761752454000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.15376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,16]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/bju.15376"],"URL":"https:\/\/doi.org\/10.1111\/bju.15376","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,16]]},"assertion":[{"value":"2021-05-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}