{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T22:34:00Z","timestamp":1788129240261,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess trends in the incidence, disease management and survival rates for upper urinary tract urothelial carcinoma (UTUC) in the Netherlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Patients diagnosed with primary UTUC in the Netherlands between 1993 and 2017 were identified through the population\u2010based Netherlands Cancer Registry (NCR). Patient and tumour characteristics, as well as information on treatment and vital status, were retrieved from the NCR. Age\u2010standardized incidence rates were calculated, stratified by age, gender, calendar period and disease stage. Relative survival served as an approximation for cancer\u2010specific survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 13\u00a0314 patients with primary UTUC. The age\u2010standardized incidence rate increased from 2.0 in 1993 to 3.2 per 100\u00a0000 person\u2010years in 2017, without change in gender distribution. The increase in incidence held for all disease stages except organ\u2010confined (T1\u2013T2) disease. The most prominent increase was in superficial (Tis\/Ta) and metastatic (M+) UTUC, which increased from 0.6 to 1.2 and 0.1 to 0.4 per 100\u00a0000 person\u2010years, respectively. The 5\u2010year relative survival did not change over time: 57.0% (95% confidence interval 55.9\u201358.1). Applied treatments were largely the same over the study period, although fewer radical nephroureterectomies and more kidney\u2010sparing surgeries were performed in the most recent years. The use of peri\u2010operative intravesical chemotherapy modestly increased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Between 1993 and 2017, the age\u2010standardized incidence of primary UTUC in the Netherlands has increased by more than 50%, but the relative survival of UTUC patients remained unchanged. Preventive measures against exposure to risk factors, early detection of disease, and more efficacious treatment methods are needed to improve outcomes of patients with UTUC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15389","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T14:55:16Z","timestamp":1615388116000},"page":"343-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Rising incidence rates and unaltered survival rates for primary upper urinary tract urothelial carcinoma: a Dutch population\u2010based study from 1993 to 2017"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9697-4293","authenticated-orcid":false,"given":"Thomas","family":"van Doeveren","sequence":"first","affiliation":[{"name":"Department of Urology Erasmus MC Cancer Institute University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"van der Mark","sequence":"additional","affiliation":[{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organisation Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim J.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Urology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost L.","family":"Boormans","sequence":"additional","affiliation":[{"name":"Department of Urology Erasmus MC Cancer Institute University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja K.H.","family":"Aben","sequence":"additional","affiliation":[{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organisation Utrecht The Netherlands"},{"name":"Radboud Institute for Health Sciences Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.05.042"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08838.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.08.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2012.32"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24339"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.07.036"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-016-1928-x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2012.05.010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.06.007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30415-3"},{"key":"e_1_2_6_12_1","volume-title":"International Classification of Disease for Oncology","author":"Fritz A","year":"2001"},{"key":"e_1_2_6_13_1","volume-title":"TNM Classification of Malignant Tumors","author":"Sobin LH","year":"2009"},{"key":"e_1_2_6_14_1","first-page":"159","article-title":"Cancer registration: principles and methods: analysis of survival","author":"Parkin DM","year":"1991","journal-title":"IARC Sci Publ"},{"key":"e_1_2_6_15_1","unstructured":"EdererF.Instructions to Ibm 650 Programmers in Processing Survival Computations. 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