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Cross\u2010sectional areas of psoas muscle, visceral and subcutaneous fat were measured at the L3 vertebral level. Functional Assessment of Chronic Illness Therapy \u2013 Fatigue questionnaire and 36\u2010item short\u2010form health survey were used to assess quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 60 included patients lost a mean (\n                      <jats:sc>sd)<\/jats:sc>\n                      of 7.8\u00a0(8.2)% of subcutaneous fat, 9.8\u00a0(18.2)% of visceral fat, and gained 12.2\u00a0(6.7)% muscle mass. Changes in subcutaneous and visceral fat were positively correlated with each other (Spearman\u2019s correlation coefficient 0.58, 95% confidence interval 0.35\u20130.71) independent of the effects of age, body mass index, and duration of androgen\u2010deprivation therapy. Energy, physical function, and measures of limitations due to physical health were all significantly improved at 3\u00a0months. The improvements in body composition were not correlated with decreases in lipid levels or observed improvements in quality of life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the present study, BAT was associated with significant improvements in body composition, lipid parameters, and quality of life. This has promising implications for the long\u2010term health of men with mCRPC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15408","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T16:07:55Z","timestamp":1616688475000},"page":"366-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Reversing the effects of androgen\u2010deprivation therapy in men with metastatic castration\u2010resistant prostate cancer"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2653-4110","authenticated-orcid":false,"given":"Catherine H.","family":"Marshall","sequence":"first","affiliation":[{"name":"Department of Oncology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessa","family":"Tunacao","sequence":"additional","affiliation":[{"name":"Department of Radiology 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