{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:16:20Z","timestamp":1785402980688,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate bacille Calmette\u2013Gue\u0301rin (BCG) tolerability and response with respect to the timing of BCG administration after transurethral resection of bladder tumour (TURBT) in patients with non\u2010muscle\u2010invasive bladder cancer (NMIBC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A review of patients with NMIBC at our institution managed with at least \u2018adequate BCG\u2019 (defined by the United States Food and Drug Administration as at least five of six induction instillations, with two additional instillations comprising either maintenance or repeat induction) at our institution from 2000 to 2018 was performed. Time from TURBT to first instillation of induction BCG was stratified by quartile and analysed as a continuous variable. Kaplan\u2013Meier and log\u2010rank tests analysed differences in recurrence\u2010free (RFS) and progression\u2010free survival (PFS). Cox proportional hazards regression models identified associations between risk factors and survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 518 patients received adequate BCG at a median (range) of 26\u00a0(6\u2013188)\u00a0days from TURBT. Overall, 45 patients (9%) developed BCG intolerance at a median (range) 12 (7\u201033) instillations. When time from TURBT to BCG was stratified into quartiles, there was no difference with respect BCG intolerance (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.966), RFS (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.632) or PFS (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.789). On both uni\u2010 and multivariate regression analysis for RFS and PFS, time from TURBT to BCG was not a significant predictor when analysed by quartile or as a continuous variable (the hazard ratio for RFS was 1.00, 95% confidence interval [CI] 0.99\u20131.00,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.449; and for PFS was 0.99, 95% CI 0.98\u20131.00,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.074).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The rates of tolerability and response to adequate BCG are not predicated by the timing of induction BCG instillation after TURBT. Early administration in properly selected patients is safe and delays do not affect therapeutic response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15413","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T11:48:07Z","timestamp":1617104887000},"page":"634-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Time interval from transurethral resection of bladder tumour to bacille Calmette\u2013Gu\u00e9rin induction does not impact therapeutic response"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8098-901X","authenticated-orcid":false,"given":"Patrick J.","family":"Hensley","sequence":"first","affiliation":[{"name":"Department of Urology University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly K.","family":"Bree","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Matulay","sequence":"additional","affiliation":[{"name":"Department of Urology Levine Cancer Institute Atrium Health Charlotte NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1274-7200","authenticated-orcid":false,"given":"Roger","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Oncology Moffitt Cancer Center Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela M.","family":"Nogueras Gonza\u0301lez","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neema","family":"Navai","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert B.","family":"Grossman","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin P.","family":"Dinney","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish M.","family":"Kamat","sequence":"additional","affiliation":[{"name":"Department of Urology University 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