{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:50:21Z","timestamp":1761760221456,"version":"build-2065373602"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008397","name":"Velux Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether a risk score for prostate cancer (PCa) lifetime risk can be used to optimise triaging of patients with a negative prostate biopsy, but under sustained suspicion of PCa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>In this prospective clinical study, we included, and risk scored patients who had a PCa\u2010negative transrectal ultrasonography (TRUS)\u2010guided prostate biopsy, but elevated prostate\u2010specific antigen (PSA), a suspicious prostate digital rectal examination and\/or a positive family history (FH) of PCa. The risk score estimated individual lifetime risk of PCa, based on a polygenic risk score (33 single nucleotide polymorphisms), age, and FH of PCa. Patients were followed, under urological supervision, for up to 4\u00a0years with annual controls, always including PSA measurements. Multiparametric magnetic resonance imaging (mpMRI) and\/or prostate biopsy was performed at selected annual controls depending on risk score and at the urologist\u2019s\/patient\u2019s discretion, which means that the follow\u2010up differed based on the risk score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 429 patients. After risk scoring, 376\/429 (88%) patients were allocated to a normal\u2010risk group (&lt;30% PCa lifetime risk) and 53\/429 (12%) to a high\u2010risk group (\u226530% PCa lifetime risk). The high\u2010risk group had significantly different follow\u2010up, with more biopsy and mpMRI sessions compared to the normal\u2010risk group. PCa was detected in 89\/429 (21%) patients, with 67\/376 (18%) patients diagnosed in the normal\u2010risk group and 22\/53 (42%) in the high\u2010risk group. There was no statistically significant difference in the cumulative incidence of PCa between the normal\u2010risk group and the high\u2010risk group after 4\u00a0years of follow\u2010up. Currently, 67\/429 (16%) patients are still being followed in this ongoing study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a 4\u2010year perspective, our PCa lifetime risk score did not demonstrate significant prognostic value for triaging patients, with a negative TRUS\u2010guided biopsy and sustained suspicion of PCa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15443","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T03:33:25Z","timestamp":1620531205000},"page":"702-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk stratification in men with a negative prostate biopsy: an interim analysis of a prospective cohort study"],"prefix":"10.1111","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7689-4096","authenticated-orcid":false,"given":"Mads","family":"Sandahl","sequence":"first","affiliation":[{"name":"Department of Radiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bodil Ginnerup","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Radiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedicte Parm","family":"Ulh\u00f8i","sequence":"additional","affiliation":[{"name":"Department of Pathology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Borre","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Department of Urology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4902-5490","authenticated-orcid":false,"given":"Karina Dalsgaard","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Department of Molecular Medicine (MOMA) Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113162"},{"key":"e_1_2_9_4_1","unstructured":"DaProCa\u2010Kliniske retningslinjer for prostata cancer 2020. 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