{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T15:13:14Z","timestamp":1785597194723,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672547"],"award-info":[{"award-number":["81672547"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872107"],"award-info":[{"award-number":["81872107"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902577"],"award-info":[{"award-number":["81902577"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974398"],"award-info":[{"award-number":["81974398"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the genetic alterations of patients with prostate cancer (PCa) with and without intraductal carcinoma of the prostate (IDC\u2010P).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We performed targeted sequencing of plasma cell\u2010free DNA on 161 patients with prostate adenocarcinoma (PAC) with IDC\u2010P and 84 without IDC\u2010P. Genomic alterations were compared between these two groups. The association between genetic alterations and patients\u2019 survival outcomes was also explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified that 29.8% (48\/161) and 21.4% (18\/84) of patients with and without IDC\u2010P harboured genomic alterations in DNA repair pathways, respectively (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.210). Pathogenic germline DNA repair alterations were frequently detected in IDC\u2010P carriers compared to IDC\u2010P non\u2010carriers (11.8% [19\/161] vs 2.4% [two of 84],\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.024). Germline BReast CAncer type 2 susceptibility protein (\n                      <jats:italic>BRCA2<\/jats:italic>\n                      ) and somatic cyclin\u2010dependent kinase 12 (\n                      <jats:italic>CDK12<\/jats:italic>\n                      ) defects were specifically identified in IDC\u2010P carriers relative to PAC (\n                      <jats:italic>BRCA2<\/jats:italic>\n                      : 8.7% [14\/161] vs 0% and\n                      <jats:italic>CDK12<\/jats:italic>\n                      : 6.8% [11\/161] vs 1.2% [one of 84]). Patients with IDC\u2010P had a distinct androgen receptor (AR) pathway alteration, characterised by an enrichment of nuclear receptor corepressor 2 (\n                      <jats:italic>NCOR2<\/jats:italic>\n                      ) mutations compared with patients with pure PAC (21.1% [34\/161] vs 6.0% [five of 84],\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.004). Increased\n                      <jats:italic>AR<\/jats:italic>\n                      alterations were detected in patients harbouring tumours with an IDC\u2010P proportion of \u226510% vs those with an IDC\u2010P proportion of &lt;10% (6.4% [five of 78] vs 18.1% [15\/83],\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.045). For IDC\u2010P carriers, tumour protein p53 (\n                      <jats:italic>TP53<\/jats:italic>\n                      ) mutation was associated with shorter castration\u2010resistant\u2010free survival (median 10.9 vs 28.9\u2009months,\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.026), and\n                      <jats:italic>BRCA2<\/jats:italic>\n                      alteration was related to rapid prostate\u2010specific antigen progression for those receiving abiraterone treatment (median 9.1 vs 11.9\u2009months,\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.036).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings provide genomic evidence explaining the aggressive phenotype of tumours with IDC\u2010P, highlighting the potential therapeutic strategies for this patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15530","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T14:46:52Z","timestamp":1624978012000},"page":"345-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Circulating tumour DNA reveals genetic traits of patients with intraductal carcinoma of the prostate"],"prefix":"10.1111","volume":"129","author":[{"given":"Jinge","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindong","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junru","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengni","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchao","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry and Molecular Biology and Urology Mayo Clinic College of Medicine and Science Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry and Molecular Biology and Urology Mayo Clinic College of Medicine and Science Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyi","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Pathology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Pathology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pathology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banghua","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron M.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Urology University of California Davis Davis CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen C.","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Urology University of California Davis Davis CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Huang","sequence":"additional","affiliation":[{"name":"3DMedicines Inc. Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1267-0509","authenticated-orcid":false,"given":"Hao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.02.028"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.03.013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.08.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.04.034"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14043"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19520"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.10.016"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.12.042"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0652-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp698"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4199-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10110926"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-0168"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902651116"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.06.004"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603144"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.001"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI132031"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00046"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506859"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.04.034"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00468-9"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305153200"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0937"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11060805"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2135-x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.02.023"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.01.035"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.15530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bju.15530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.15530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T10:24:57Z","timestamp":1761733497000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.15530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/bju.15530"],"URL":"https:\/\/doi.org\/10.1111\/bju.15530","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,3]]},"assertion":[{"value":"2021-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}