{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:47:40Z","timestamp":1780400860482,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the outcomes of pre\u2010biopsy magnetic resonance imaging (MRI) pathways, as a tool in biopsy\u2010na\u00efve men with suspicion of prostate cancer, in routine clinical practice. Secondary outcomes included a comparison of transrectal MRI\u2010directed biopsy (TR\u2010MRDB) and transperineal (TP)\u2010MRDB in men with suspicious MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We retrospectively assessed a two\u2010centre cohort of consecutive biopsy\u2010na\u00efve men with suspicion of prostate cancer who underwent a Prostate Imaging\u2010Reporting and Data System version 2 (PI\u2010RADS v2) compliant pre\u2010biopsy MRI in a single, high\u2010volume centre between 2015 and 2019 (Centre 1). Men with suspicious MRI scans underwent TR\u2010MRDB in Centre 1 and TP\u2010MRDB with additional random biopsies (RB) in Centre 2. The MRI and histopathology were assessed in the same institution (Centre 1). Outcomes included: (i) overall detection rates of Grade Group (GG) 1, GG \u22652, and GG \u22653 cancer in men with suspicious MRI; (ii) Biopsy\u2010avoidance due to non\u2010suspicious MRI; and (iii) Cancer detection rates and biopsy\u2010related complications between TR\u2010 and TP\u2010MRDB. To reduce confounding bias for MRDB comparisons, inverse probability weighting (IPW) was performed for age, digital rectal examination, prostate\u2010specific antigen (PSA), prostate volume, PSA density, and PI\u2010RADS category.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 2597 men included, the overall GG 1, GG \u22652, and GG \u22653 prevalence was 8% (210\/2597), 27% (697\/2597), and 15% (396\/2597), respectively. Biopsy was avoided in 57% (1488\/2597) of men. After IPW, the GG 1, GG \u22652 and GG \u22653 detection rates after TR\u2010 and TP\u2010MRDB were comparable at 24%, 57%, and 32%; and 18%, 64%, and 38%, respectively; with mean differences of \u22125.7% (95% confidence interval [CI] \u221213% to 1.4%), 6.1% (95% CI \u22122.1% to 14%), and 5.7% (95% CI \u22121.7% to 13%). Complications were similar in TR\u2010MRDB (0.50%) and TP\u2010MRDB with RB (0.62%; mean difference 0.11%, 95% CI \u22120.87% to 1.1%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This high\u2010volume, two\u2010centre study shows pre\u2010biopsy MRI as a decision tool is implementable in daily clinical practice. Compared to recent trials, a substantially higher biopsy avoidance rate was achieved without compromising GG \u22652\/GG \u22653 detection and coinciding with lower over detection rates of GG 1 cancer. Prostate cancer detection and complication rates were comparable for TR\u2010 and TP\u2010MRDB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15562","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T14:53:32Z","timestamp":1628261612000},"page":"480-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical implementation of pre\u2010biopsy magnetic resonance imaging pathways for the diagnosis of prostate cancer"],"prefix":"10.1111","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4848-4537","authenticated-orcid":false,"given":"Bas","family":"Isra\u00ebl","sequence":"first","affiliation":[{"name":"Department of Medical Imaging Radboud University Medical Center Radboud Institute for Health Sciences Nijmegen the Netherlands"},{"name":"Department of Urology Radboud University Medical Center Radboud Institute for Health Sciences Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"Immerzeel","sequence":"additional","affiliation":[{"name":"Department of Urology Andros Clinics Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marloes","family":"van der Leest","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Radboud University Medical Center Radboud Institute for Health Sciences Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerjon","family":"Hannink","sequence":"additional","affiliation":[{"name":"Department of Operating Rooms Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Z\u00e1mecnik","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Radboud University Medical Center Radboud Institute for Health Sciences Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Bomers","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Radboud University Medical Center Radboud Institute for Health Sciences Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9804-0603","authenticated-orcid":false,"given":"Ivo G.","family":"Schoots","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Erasmus University Medical Center Rotterdam the Netherlands"},{"name":"Department of Radiology Netherlands Cancer Institute Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul","family":"van Basten","sequence":"additional","affiliation":[{"name":"Department of Urology Canisius Wilhelmina Hospital Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans","family":"Debruyne","sequence":"additional","affiliation":[{"name":"Department of Urology Andros Clinics Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"van Oort","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Medical Center Radboud Institute for Health Sciences Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Sedelaar","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Medical Center Radboud Institute for Health Sciences Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelle","family":"Barentsz","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Radboud University Medical Center Radboud Institute for Health Sciences Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"FerlayJ ErvikM LamFet\u2009al.Global cancer observatory: cancer tomorrow.2018. 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