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Men are disproportionately affected by COVID\u201019, having more severe disease with higher mortality rates than women. Androgens have been implicated as the underlying cause for more severe disease, as the androgen receptor has been noted to upregulate the cell surface receptors that mediate viral cell entry and infection. Unfortunately, despite testosterone\u2019s potential role in COVID\u201019 prognosis, androgen deprivation therapy is neither protective nor a treatment for COVID\u201019. Interestingly, the male reproductive organs have been found to be vulnerable in moderate to severe illness, leading to reports of erectile dysfunction and orchitis. COVID\u201019 viral particles have been identified in penile and testis tissue, both in live patients who recovered from COVID\u201019 and post mortem in men who succumbed to the disease. Although sexual transmission remains unlikely in recovered men, moderate to severe COVID\u201019 infection can lead to germ cell and Leydig cell depletion, leading to decreased spermatogenesis and male hypogonadism. The objective of this review is to describe the impact of SARS\u2010CoV\u20102 on male reproductive health. There are still many unanswered questions as to the specific underlying mechanisms by which COVID\u201019 impacts male reproductive organs and the long\u2010term sequelae of SARS\u2010CoV\u20102 on male reproductive health.<\/jats:p>","DOI":"10.1111\/bju.15573","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T04:35:33Z","timestamp":1629174933000},"page":"143-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Impact of the SARS\u2010CoV\u20102 virus on male reproductive health"],"prefix":"10.1111","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6884-4299","authenticated-orcid":false,"given":"Daniel E.","family":"Nassau","sequence":"first","affiliation":[{"name":"Department of Urology University of Miami Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan C.","family":"Best","sequence":"additional","affiliation":[{"name":"Department of Urology University of Miami Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliyahu","family":"Kresch","sequence":"additional","affiliation":[{"name":"Department of Urology University of Miami Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel C.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Urology University of Miami Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kajal","family":"Khodamoradi","sequence":"additional","affiliation":[{"name":"Department of Urology University of Miami Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjith","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Department of Urology University of Miami Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Weekly operational update on COVID\u201019 \u2010 24 May 2021 [Internet]. 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