{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:34:47Z","timestamp":1771061687354,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the role of blue\u2010light cystoscopy (BLC) in detecting invasive tumours that were not visible on white\u2010light cystoscopy (WLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Using the multi\u2010institutional Cysview registry database, patients who had at least one white\u2010light negative (WL\u2013)\/blue\u2010light positive (BL+) lesion with invasive pathology (\u2265T1) as highest stage tumour were identified. All WL\u2013\/BL+ lesions and all invasive tumours in the database were used as denominators. Relevant baseline and outcome data were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 3514 lesions (1257 unique patients), 818 (23.2%) lesions were WL\u2212\/BL+, of those, 55 (7%) lesions were invasive (48 T1, seven T2; 47 unique patients) including 28\/55 (51%)\n                      <jats:italic>de novo<\/jats:italic>\n                      invasive lesions (26 unique patients). In all, 21\/47 (45%) patients had WL\u2212\/BL+ concommitant carcinoma\n                      <jats:italic>in\u00a0situ<\/jats:italic>\n                      and\/or another T1 lesions. Of 22 patients with a WL\u2212\/BL+ lesion who underwent radical cystectomy (RC), high\u2010risk pathological features leading to RC was only visible on BLC in 18 (82%) patients. At time of RC, 11\/22 (50%) patients had pathological upstaging including four (18%) with node\u2010positive disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A considerable proportion of invasive lesions are only detectable by BLC and the rate of pathological upstaging is significant. Our present findings suggest an additional benefit of BLC in the detection of invasive bladder tumours that has implications for treatment approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15614","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:25:49Z","timestamp":1634084749000},"page":"62-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of blue\u2010light cystoscopy in detecting invasive bladder tumours: data from a multi\u2010institutional registry"],"prefix":"10.1111","volume":"130","author":[{"given":"Hamed","family":"Ahmadi","sequence":"first","affiliation":[{"name":"Department of Urology USC Norris Comprehensive Cancer Center University of Southern California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-1556","authenticated-orcid":false,"given":"Seyedeh Sanam","family":"Ladi\u2010Seyedian","sequence":"additional","affiliation":[{"name":"Department of Urology USC Norris Comprehensive Cancer Center University of Southern California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badrinath","family":"Konety","sequence":"additional","affiliation":[{"name":"University of Minnesota  Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Pohar","sequence":"additional","affiliation":[{"name":"Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Holzbeierlein","sequence":"additional","affiliation":[{"name":"University of Kansas  Kansas City KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Kates","sequence":"additional","affiliation":[{"name":"The James Buchanan Brady Urological Institute Johns Hopkins University  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Willard","sequence":"additional","affiliation":[{"name":"Lexington Medical Center  Lexington SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Michael E. DeBakey VAMC BCM  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph C.","family":"Liao","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System  Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hristos Z.","family":"Kaimakliotis","sequence":"additional","affiliation":[{"name":"Department of Urology Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sima P.","family":"Porten","sequence":"additional","affiliation":[{"name":"Department of Urology University of California San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary D.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Department of Urology New York University  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark 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