{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:22:28Z","timestamp":1791397348084,"version":"4.3.3"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyse the incidence, treatment strategies and complications associated with penile intraepithelial neoplasia (PeIN) in Sweden over a period of 20\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Data on PeIN from the Swedish National Penile Cancer Register were analysed regarding treatment in relation to age, size of the PeIN lesion, localization of the PeIN lesion and complications using chi\u2010squared tests and logistic regression. The incidence of PeIN was calculated and age\u2010standardized according to the European Standard population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between 2000 and 2019 a total of 1113 PeIN cases were reported. The age\u2010standardized incidence of PeIN was 1.40 per 100\u2009000 men (95% confidence interval [CI] 1.32\u20131.49). An increase in incidence over time was seen, with a standardized incidence rate of 2.37 (95% CI 1.56\u20133.70) in 2019 compared to the baseline year, 2000. Surgical or topical treatments were given in 75.0% and 14.6% of cases, respectively. The complication rate was higher in laser surgery (12.1%, 7\/58) compared to local surgery (4.6%, 16\/348;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.03) with an age\u2010adjusted odds ratio (OR) of 2.82 (95% CI 1.10\u20137.19;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.03). Local surgery was more common than laser surgery in the last 5\u2009years compared to the first 5\u2009years of the study period: OR 5.75 (95% CI 2.94\u201311.27). Treatments with imiquimod and topical 5\u2010fluorouracil (5\u2010FU) were more common than destructive methods such as photodynamic therapy, cryotherapy, curettage and electrocautery in the last 5\u2009years compared to the first 5\u2009years: OR 9.48 (95% CI 2.29\u201339.24).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A twofold increase in the age\u2010standardized incidence of PeIN was seen in Sweden over 20\u2009years. Complications were three times more common in laser surgery compared to local surgery. Changes in treatment showed an increase of treatment strategies such as local surgery and treatment with imiquimod and topical 5\u2010FU over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15688","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T06:49:44Z","timestamp":1642574984000},"page":"752-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Incidence of penile intraepithelial neoplasia and treatment strategies in Sweden 2000\u20132019"],"prefix":"10.1111","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0584-5574","authenticated-orcid":false,"given":"Sinja","family":"Kristiansen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Skane University Hospital, Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Torbrand","sequence":"additional","affiliation":[{"name":"Department of Urology Helsingborg Hospital  Helsingborg Sweden"},{"name":"Institution of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5ke","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Skane University Hospital, Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Forslund","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, Department of Medical Microbiology Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Bjartling","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Skane University Hospital, Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Cancer Incidence in Five Continents","author":"Curado MP","year":"2007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12993"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25355"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.02.029"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3083"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12766"},{"key":"e_1_2_8_9_1","unstructured":"HakenbergOW CE MinhasS NecchiA ProtzelC WatkinN RobinsonR.EAU Guidelines on Penile Cancer. 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