{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:35:09Z","timestamp":1790714109812,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","award":["96\/20\/99"],"award-info":[{"award-number":["96\/20\/99"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","award":["96\/20\/06"],"award-info":[{"award-number":["96\/20\/06"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the functional and quality of life (QoL) outcomes of treatments for localised prostate cancer and inform treatment decision\u2010making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Men aged 50\u201369\u2009years diagnosed with localised prostate cancer by prostate\u2010specific antigen testing and biopsies at nine UK centres in the Prostate Testing for Cancer and Treatment (ProtecT) trial were randomised to, or chose one of, three treatments. Of 2565 participants, 1135 men received active monitoring (AM), 750 a radical prostatectomy (RP), 603 external\u2010beam radiotherapy (EBRT) with concurrent androgen\u2010deprivation therapy (ADT) and 77 low\u2010dose\u2010rate brachytherapy (BT, not a randomised treatment). Patient\u2010reported outcome measures (PROMs) completed annually for 6\u2009years were analysed by initial treatment and censored for subsequent treatments. Mixed effects models were adjusted for baseline characteristics using propensity scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Treatment\u2010received analyses revealed different impacts of treatments over 6\u2009years. Men remaining on AM experienced gradual declines in sexual and urinary function with age (e.g., increases in erectile dysfunction from 35% of men at baseline to 53% at 6\u2009years and nocturia similarly from 20% to 38%). Radical treatment impacts were immediate and continued over 6\u2009years. After RP, 95% of men reported erectile dysfunction persisting for 85% at 6\u2009years, and after EBRT this was reported by 69% and 74%, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 compared with AM). After RP, 36% of men reported urinary leakage requiring at least 1\u2009pad\/day, persisting for 20% at 6\u2009years, compared with no change in men receiving EBRT or AM (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Worse bowel function and bother (e.g., bloody stools 6% at 6\u2009years and faecal incontinence 10%) was experienced by men after EBRT than after RP or AM (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) with lesser effects after BT. No treatment affected mental or physical QoL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment decision\u2010making for localised prostate cancer can be informed by these 6\u2010year functional and QoL outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15739","type":"journal-article","created":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T22:50:19Z","timestamp":1649026219000},"page":"370-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Functional and quality of life outcomes of localised prostate cancer treatments (Prostate Testing for Cancer and Treatment\n                    <scp>[ProtecT]<\/scp>\n                    study)"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7578-4925","authenticated-orcid":false,"given":"Janet Athene","family":"Lane","sequence":"first","affiliation":[{"name":"Bristol Medical School University of Bristol  Bristol UK"},{"name":"Bristol Medical School Bristol Trials Centre University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny L.","family":"Donovan","sequence":"additional","affiliation":[{"name":"Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace J.","family":"Young","sequence":"additional","affiliation":[{"name":"Bristol Medical School University of Bristol  Bristol UK"},{"name":"Bristol Medical School Bristol Trials Centre University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Davis","sequence":"additional","affiliation":[{"name":"Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor I.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry N.L.","family":"Avery","sequence":"additional","affiliation":[{"name":"Bristol Medical School University of Bristol  Bristol UK"},{"name":"Bristol Medical School NIHR Bristol Biomedical Research Centre University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane M.","family":"Blazeby","sequence":"additional","affiliation":[{"name":"Bristol Medical School University of Bristol  Bristol UK"},{"name":"Bristol Medical School NIHR Bristol Biomedical Research Centre University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm D.","family":"Mason","sequence":"additional","affiliation":[{"name":"School of Medicine Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7992-7719","authenticated-orcid":false,"given":"Richard M.","family":"Martin","sequence":"additional","affiliation":[{"name":"Bristol Medical School University of Bristol  Bristol UK"},{"name":"Bristol Medical School NIHR Bristol Biomedical Research Centre University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.","family":"Peters","sequence":"additional","affiliation":[{"name":"Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"Turner","sequence":"additional","affiliation":[{"name":"Bristol Medical School University of Bristol  Bristol 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