{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:20:22Z","timestamp":1777400422444,"version":"3.51.4"},"reference-count":85,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T00:00:00Z","timestamp":1652572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To summarise the causes of ureteric damage and the current standard of care, discussing the risks and benefits of available therapeutic options. We then focus on the current and future solutions that can be provided by ureteric bioengineering and provide a description of the ideal characteristics of a bioengineered product.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a literature search in February 2021 in: Google Scholar, Medline, and Web of Science. Three searches were conducted, investigating: (a) the epidemiology of ureteric pathology, (b) the current standard of care, and (c) the state of the art in ureteric bioengineering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The most\u2010common causes of ureteric damage are iatrogenic injury and external trauma. Current approaches to treatment include stent placement or surgical reconstruction. Reconstruction can be done using either urological tissue or segments of the gastrointestinal tract. Limitations include scarring, strictures, and infections. Several bioengineered alternatives have been explored in animal studies, with variations in the choice of scaffold material, cellular seeding populations, and pre\u2010implantation processing. Natural grafts and hybrid material appear to be associated with superior outcomes. Furthermore, seeding of the scaffold material with stem cells or differentiated urothelial cells allows for better function compared to acellular scaffolds. Some studies have attempted to pre\u2010implant the graft in the omentum prior to reconstruction, but this has yet to prove any definitive benefits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is an unmet clinical need for safer and more effective treatment for ureteric injuries. Urological bioengineering is a promising solution in preclinical studies. However, substantial scientific, logistic, and economic challenges must be addressed to harness its transformative potential in improving outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15741","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T01:13:27Z","timestamp":1649294007000},"page":"408-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Bioengineering solutions for ureteric disorders: clinical need, challenges and opportunities"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0734-3474","authenticated-orcid":false,"given":"Konstantinos","family":"Kapetanos","sequence":"first","affiliation":[{"name":"School of Clinical Medicine University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-3651","authenticated-orcid":false,"given":"Alexander","family":"Light","sequence":"additional","affiliation":[{"name":"Department of Urology Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niyukta","family":"Thakare","sequence":"additional","affiliation":[{"name":"Department of Urology Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnaa","family":"Mahbubani","sequence":"additional","affiliation":[{"name":"Cambridge Biorepository for Translational Medicine (CBTM) NIHR Cambridge Biomedical Research Centre  Cambridge UK"},{"name":"Department of Haematology University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasra","family":"Saeb\u2010Parsy","sequence":"additional","affiliation":[{"name":"Department of Urology Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kourosh","family":"Saeb\u2010Parsy","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Cambridge and Cambridge NIHR Biomedical Research Centre  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287214526767"},{"key":"e_1_2_10_3_1","volume-title":"Ureteral Injury. 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