{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:01:21Z","timestamp":1785445281876,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014527","name":"Healthcare Quality Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014527","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014461","name":"NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust\/Institute of Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014461","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005622","name":"Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop and validate a coding framework to identify interventions for upper tract obstructive uropathy (UTOU) in men with locally advanced and metastatic prostate cancer (PCa) using administrative hospital data to assess clinical outcomes. There are no population\u2010based studies on the incidence, treatment, and outcomes of this complication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Patients newly diagnosed with PCa between April 2014 and March 2019 were identified in the English cancer registry. A coding framework based on procedure (Office of Population Censuses and Surveys Classification of Surgical Operations and Procedures fourth edition) and diagnostic (International Classification of Diseases, 10th edition) codes was developed and validated. Subsequent clinical outcomes were determined using Hospital Episodes Statistics to determine the utility of the intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 77\u2009010 patients newly diagnosed with locally advanced, and 30\u2009083 patients with metastatic PCa were identified. Of these, 1951 (1.8%) patients underwent an intervention for UTOU according to our coding framework: 830 (42.5%) had locally advanced disease and 1121 (57.5%) had metastatic disease. In all, 844 (43.3%) had a percutaneous nephrostomy (PCN), 473 (24.2%) had a PCN with antegrade stent, and 634 (32.5%) had a retrograde stent. The mean follow\u2010up was 43.2\u2009months. The cumulative incidence of the use of these interventions at 1, 3, and 5\u2009years was 2.5%, 3.6% and 4.2% in men with metastases compared to 0.5%, 0.9% and 1.4% in men with locally advanced disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A new coding framework, developed to identify procedures for UTOU was applied in the largest study to date of UTOU in men with primary locally advanced and metastatic PCa. Results demonstrated that 2% of men with locally advanced PCa and 4% of men with metastatic PCa require an intervention to resolve UTOU within 5\u2009years of their PCa diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15766","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:14:18Z","timestamp":1651209258000},"page":"688-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Interventions for obstructive uropathy in advanced prostate cancer: a population\u2010based study"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8572-2832","authenticated-orcid":false,"given":"Arjun","family":"Nathan","sequence":"first","affiliation":[{"name":"Clinical Effectiveness Unit The Royal College of Surgeons of England  London UK"},{"name":"Division of Surgery and Interventional Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Morris","sequence":"additional","affiliation":[{"name":"Clinical Effectiveness Unit The Royal College of Surgeons of England  London UK"},{"name":"Department of Health Services Research and Policy London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9695-6052","authenticated-orcid":false,"given":"Matthew G.","family":"Parry","sequence":"additional","affiliation":[{"name":"Clinical Effectiveness Unit The Royal College of Surgeons of England  London UK"},{"name":"Department of Health Services Research and Policy London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Berry","sequence":"additional","affiliation":[{"name":"Clinical Effectiveness Unit The Royal College of Surgeons of England  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1304-3942","authenticated-orcid":false,"given":"Arunan","family":"Sujenthiran","sequence":"additional","affiliation":[{"name":"Clinical Effectiveness Unit The Royal College of Surgeons of England  London UK"},{"name":"Flatiron Health  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-7624","authenticated-orcid":false,"given":"Julie","family":"Nossiter","sequence":"additional","affiliation":[{"name":"Clinical Effectiveness Unit The Royal College of Surgeons of England  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Payne","sequence":"additional","affiliation":[{"name":"Department of Oncology University College London Hospitals  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-2335","authenticated-orcid":false,"given":"Jan","family":"Van Der Meulen","sequence":"additional","affiliation":[{"name":"Clinical Effectiveness Unit The Royal College of Surgeons of England  London UK"},{"name":"Department of Health Services Research and Policy London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel W.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Urology The Christie and Salford Royal NHS Foundation Trusts Manchester  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S. A.","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Urology Whipps Cross Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2006.0185"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11193.x"},{"issue":"4","key":"e_1_2_12_4_1","first-page":"404","article-title":"Role of percutaneous nephrostomy in end of life prostate cancer patients: A systematic review of the literature. Central European","volume":"71","author":"New F","year":"2018","journal-title":"Journal of Urology"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02466-2"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2003.10.021"},{"key":"e_1_2_12_7_1","unstructured":"NationalProstateCancerAudit.Annual Report2020. 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