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The impact on rectal dosimetry has been clearly established and use of hydrogel spacers is associated with reduced rectal morbidity. These results have been corroborated by several Phase II and III clinical trials and subsequent meta\u2010analysis. There are several areas for future research, including the role of hydrogel spacers in prostate stereotactic beam radiotherapy and post\u2010radiotherapy local recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hydrogel spacers provide a low\u2010morbidity method to potential reduce rectal toxicity after radiation therapy in men with prostate cancer. Data outlining sexual function and oncological outcomes are limited to date. Future studies, currently being conducted, may provide further clarification of the role of hydrogel spacers in prostate cancer management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15821","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T02:48:34Z","timestamp":1654915714000},"page":"280-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Comprehensive review of the use of hydrogel spacers prior to radiation therapy for prostate cancer"],"prefix":"10.1111","volume":"131","author":[{"given":"Michael","family":"Harvey","sequence":"first","affiliation":[{"name":"Urology Department Austin Health  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wee Loon","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Alfred Health  Melbourne Vic. 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