{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:50:35Z","timestamp":1792050635112,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772755"],"award-info":[{"award-number":["81772755"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the anti\u2010tumour activity and safety of anti\u2010programmed death receptor\u20101 (PD\u20101) antibody plus epidermal growth factor receptor blockade combined with platinum\u2010based chemotherapy (PEP) as first\u2010line therapy for stage IV penile squamous cell carcinoma (PSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective review of 17 patients with stage IV PSCC undergoing first\u2010line PEP at Sun Yat\u2010sen University Cancer Center between January 2018 and September 2021. Clinical responses were assessed using the Response Evaluation Criteria in Solid Tumours (RECIST) version 1.1. Progression\u2010free survival (PFS) and overall survival (OS) were estimated using the Kaplan\u2013Meier method. Adverse events (AEs) were graded according to Common Terminology Criteria for Adverse Events version 5.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 17 patients who received first\u2010line PEP, 13 were observed to have partial responses. Twelve patients subsequently received consolidated surgery. Nine of these achieved pN0 status, of whom six with locally advanced PSCC achieved pathological complete response. The median (range) follow\u2010up time was 24.87\u2009(3.63\u201329.40) months. Median PFS and median OS were not reached, with 2\u2010year PFS and OS rates being 68.4% (95% confidence interval [CI] 48.7\u201396.1) and 62.9% (95% CI 41.6\u201395), respectively. Eight patients experienced Grade 3 or 4 treatment\u2010related AEs. No Grade 5 AEs or death associated with treatment was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anti\u2010PD\u20101 antibody plus epidermal growth factor receptor blockade and platinum\u2010based chemotherapy showed promising anti\u2010tumour activity, acceptable toxicity, and satisfying long\u2010term survival for stage IV PSCC. Larger clinical trials are needed to validate our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15828","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T12:25:53Z","timestamp":1655295953000},"page":"198-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["First\u2010line programmed death receptor\u20101 (\n                    <scp>PD<\/scp>\n                    \u20101) inhibitor and epidermal growth factor receptor (EGFR) blockade, combined with platinum\u2010based chemotherapy, for stage\n                    <scp>IV<\/scp>\n                    penile cancer"],"prefix":"10.1111","volume":"131","author":[{"given":"Ru","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Centre for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Centre for Cancer Medicine  Guangzhou China"},{"name":"Department of Radiology Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Centre for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Centre for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Centre for Cancer Medicine  Guangzhou China"},{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinan","family":"Sheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing) Department of Genitourinary Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Centre for Cancer Medicine  Guangzhou China"},{"name":"Department of Pathology Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe E.","family":"Spiess","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Oncology H. 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