{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:05:46Z","timestamp":1789236346485,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine the long\u2010term oncological outcomes and urological morbidity of low\u2010dose\u2010rate prostate brachytherapy (LDRBT) monotherapy using live intraoperative dosimetry planning and an automated needle navigation delivery system for the treatment of men with low and intermediate\u2010risk prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A prospective database of 400 consecutive patients who underwent LDRBT between July 2003 and June 2015 was retrospectively reviewed to assess urinary side\u2010effects and biochemical progression, based on the Phoenix definition and also a definition of a prostate\u2010specific antigen (PSA) level of \u22650.2\u2009\u03bcg\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Minimum patient follow\u2010up was 5.5\u2009years. The median follow\u2010up of the entire cohort was 11.8\u2009years. The median (range) PSA level was 6.1\u2009(0.9\u201317)\u2009\u03bcg\/L and the median Gleason score was 3\u2009+\u20094. The biochemical relapse\u2010free survival (RFS; freedom from biochemical recurrence) based on the Phoenix definition was 85.8% (343\/400). The RFS using a \u2018surgical\u2019 definition of a PSA level of &lt;0.2\u2009\u03bcg\/L was 71% (284\/400). Of the 297 men followed for \u226510\u2009years, prostate cancer\u2010specific survival (PCSS) was 98% (291\/297). Post\u2010LDRBT urethral stricture developed in 11 men (2.8%, 11\/400). For men with \u226510\u2009years of follow\u2010up, 22 men (7.4%, 22\/297) required a pad for either stress or urge urinary incontinence (UI). UI was identified in only 2.2% (one of 46) of men who had a bladder neck incision (BNI) before LDRBT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LDRBT is associated with excellent PCSS, with a median follow\u2010up of 11.8\u2009years. The risk of post\u2010implantation urethral stricture and UI is low and a pre\u2010implantation BNI for management of bladder outflow obstruction does not increase the risk of UI or urethral stricture.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15845","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T04:18:30Z","timestamp":1657081110000},"page":"40-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oncological and urinary outcomes following low\u2010dose\u2010rate brachytherapy with a median follow\u2010up of 11.8\u2009years"],"prefix":"10.1111","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4229-1411","authenticated-orcid":false,"given":"William John","family":"Yaxley","sequence":"first","affiliation":[{"name":"Queen Elizabeth II Jubilee Hospital  Brisbane QLD Australia"},{"name":"School of Medicine The University of Queensland  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Mackean","sequence":"additional","affiliation":[{"name":"Genesis Cancer Care  Brisbane QLD Australia"},{"name":"Wesley Hospital  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devang J.","family":"Desai","sequence":"additional","affiliation":[{"name":"Toowoomba Hospital  Toowoomba QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Tsang","sequence":"additional","affiliation":[{"name":"Genesis Cancer Care  Brisbane QLD Australia"},{"name":"Wesley Hospital  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judi","family":"Dixon","sequence":"additional","affiliation":[{"name":"Wesley Urology Clinic Wesley Hospital  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemamali","family":"Samaratunga","sequence":"additional","affiliation":[{"name":"Aquesta Uropathology  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Delahunt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences University of Otago  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8531-222X","authenticated-orcid":false,"given":"Lars","family":"Egevad","sequence":"additional","affiliation":[{"name":"Department of Oncology and Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Gardiner","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6566-9037","authenticated-orcid":false,"given":"John William","family":"Yaxley","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland  Brisbane QLD Australia"},{"name":"Wesley Hospital  Brisbane QLD Australia"},{"name":"Wesley Urology Clinic Wesley Hospital  Brisbane QLD Australia"},{"name":"Royal Brisbane and Women's Hospital  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10460.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.12.014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2020.02.15"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.11.018"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.10.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.07.116"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-018-0844-8"},{"key":"e_1_2_9_9_1","unstructured":"European Association of Urology.EUA guidelines: Prostate cancer.2021. 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