{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:44:47Z","timestamp":1777045487602,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000771","name":"Prostate Cancer UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To test for evidence of statin\u2010mediated effects in patients with castration\u2010resistant prostate cancer (CRPC) as post\u2010diagnosis use of statins in patients with prostate cancer is associated with favourable survival outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>The SPECTRE trial was a 6\u2010weeks\u2010long proof\u2010of\u2010concept single\u2010arm Phase II treatment trial, combining atorvastatin and androgen deprivation therapy in patients with CRPC (regardless of metastatic status), designed to test for evidence of statin\u2010mediated effects in patients with CRPC. The primary study endpoint was the proportion of patients achieving a \u226550% drop from baseline in prostate\u2010specific antigen (PSA) levels at any time over the 6\u2010week period of atorvastatin medication (PSA response). Exploratory endpoints include PSA velocity and serum metabolites identified by mass spectrometry .<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the scheduled interim analysis, one of 12 patients experienced a \u226550% drop in PSA levels (primary endpoint), with \u22652 patients satisfying the primary endpoint required for further recruitment. All 12 patients experienced substantial falls in serum cholesterol levels following statin treatment. While all patients had comparable pre\u2010study PSA velocities, six of 12 patients showed decreased PSA velocities after statin treatment, suggestive of disease stabilization. Unbiased metabolomics analysis on serial weekly blood samples identified tryptophan to be the dominant metabolite associated with patient response to statin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Data from the SPECTRE study provide the first evidence of statin\u2010mediated effects on CRPC and early sign of disease stabilization. Our data also highlight the possibility of altered tryptophan metabolism being associated with tumour response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15851","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T03:03:36Z","timestamp":1658113416000},"page":"236-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Phase\n                    <scp>II<\/scp>\n                    proof\u2010of\u2010concept study of atorvastatin in castration\u2010resistant prostate cancer"],"prefix":"10.1111","volume":"131","author":[{"given":"Linda K.","family":"Rushworth","sequence":"first","affiliation":[{"name":"Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences University of Glasgow  Glasgow UK"},{"name":"CRUK Beatson Institute  Glasgow 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