{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:21:52Z","timestamp":1791357712115,"version":"4.3.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016242","name":"Boston Scientific Japan","doi-asserted-by":"publisher","award":["na"],"award-info":[{"award-number":["na"]}],"id":[{"id":"10.13039\/100016242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,2]]},"abstract":"\n Objective<\/jats:title>\n To evaluate the relationship between renal pelvis pressure and fluid absorption during ureteroscopy (URS) in a live porcine model.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n Flexible URS (fURS) was performed in anaesthetised female Yorkshire pigs. Prior to performing fURS, a 0.3556\u2010mm (0.014\u2033) pressure\u2010sensing guidewire (Comet\u2122, Boston Scientific) was placed to monitor renal pelvis pressure. A simulated fURS procedure was then performed for 1\u2009h. Infusion of irrigation fluid (5% ethanol in saline) at target renal pelvis pressures (37\u2013150\u2009mmHg) was maintained for 1\u2009h using a pressure bag and real\u2010time feedback from the pressure\u2010sensing guidewire. Venous blood was sampled every 10\u2009min. The volume of irrigation fluid absorbed was estimated with established equations.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A URS procedure was performed in\u2009vivo in 18 porcine kidneys and the volume of irrigation fluid absorbed during the 1\u2009h URS was calculated. The mean (SD) volume of irrigation fluid absorbed after 1\u2009h of simulated URS was 7.6\u2009(5.7), 10.8\u2009(7.1), 26.0\u2009(15.8), and 56.8\u2009(22.3)\u2009mL at renal pelvis pressures of 37, 55, 75, and 150\u2009mmHg, respectively. Compared with URS with renal pelvis pressure of 37\u2009mmHg, the volume of fluid absorption was significantly greater at renal pelvis pressures of 75 and 150\u2009mmHg (\n P<\/jats:italic>\n \u2009=\u20090.026 and\n P<\/jats:italic>\n \u2009=\u20090.047, respectively). In addition, compared with URS with renal pelvis pressure of 37\u2009mmHg, the rate of absorption was significantly greater at renal pelvis pressures of 75 and 150\u2009mmHg (both\n P<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In this study of an in\u2009vivo porcine model of URS, increasing renal pelvis pressures during URS were associated with increases in irrigation fluid absorption and increases in the rate of fluid absorption.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.15858","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T04:45:54Z","timestamp":1658378754000},"page":"213-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Evaluation of fluid absorption during flexible ureteroscopy in an\n in\u2009vivo<\/i>\n porcine model"],"prefix":"10.1111","volume":"131","author":[{"given":"Christina","family":"Kottooran","sequence":"first","affiliation":[{"name":"Department of Urology, Harvard Medical School Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Twum\u2010Ampofo","sequence":"additional","affiliation":[{"name":"Department of Urology, Harvard Medical School Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology, Harvard Medical School Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Saunders","sequence":"additional","affiliation":[{"name":"Boston Scientific Corporation Marlborough MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marle","family":"Franco","sequence":"additional","affiliation":[{"name":"Boston Scientific Corporation Marlborough MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Budrewicz","sequence":"additional","affiliation":[{"name":"CBSET, Inc. Lexington MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8891-4100","authenticated-orcid":false,"given":"Brian H.","family":"Eisner","sequence":"additional","affiliation":[{"name":"Department of Urology, Harvard Medical School Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2020.1133"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1677-5538.ibju.2020.0248"},{"key":"e_1_2_7_4_1","first-page":"111","article-title":"Urology: the clinical significance of Pyelovenous backflow","volume":"29","author":"Hinman F","year":"1928","journal-title":"Calif West Med"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2378-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.1998.12.45"},{"key":"e_1_2_7_7_1","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council","year":"2011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-3383-y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2016.0513"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.05.095"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-015-1582-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-015-1114-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28433"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2013.0697"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-020-03216-w"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.15858","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bju.15858","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.15858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:28:34Z","timestamp":1761748114000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.15858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,28]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/bju.15858"],"URL":"https:\/\/doi.org\/10.1111\/bju.15858","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,28]]},"assertion":[{"value":"2022-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}