{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:31:52Z","timestamp":1779366712703,"version":"3.53.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","award":["10\/137\/01"],"award-info":[{"award-number":["10\/137\/01"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the cost\u2010effectiveness, resource use implications, quality\u2010adjusted life\u2010years (QALYs) and cost per QALY of care pathways starting with either extracorporeal shockwave lithotripsy (SWL) or with ureteroscopic retrieval (ureteroscopy [URS]) for the management of ureteric stones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Data on quality of life and resource use for 613 patients, collected prospectively in the Therapeutic Interventions for Stones of the Ureter (TISU) randomized controlled trial (ISRCTN 92289221), were used to assess the cost\u2010effectiveness of two care pathways, SWL and URS. A health provider (UK National Health Service) perspective was adopted to estimate the costs of the interventions and subsequent resource use. Quality\u2010of\u2010life data were calculated using a generic instrument, the EuroQol EQ\u20105D\u20103L. Results are expressed as incremental cost\u2010effectiveness ratios and cost\u2010effectiveness acceptability curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean QALY difference (SWL vs URS) was \u22120.021 (95% confidence interval [CI] \u22120.033 to \u22120.010) and the mean cost difference was \u2212\u00a3809 (95% CI \u2212\u00a31061 to \u2212\u00a3551). The QALY difference translated into approximately 10 more healthy days over the 6\u2010month period for the patients on the URS care pathway. The probabaility that SWL is cost\u2010effective is 79% at a society's willingness to pay (WTP) threshold for 1 QALY of \u00a330,000 and 98% at a WTP threshold of \u00a320,000.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The SWL pathway results in lower QALYs than URS but costs less. The incremental cost per QALY is \u00a339\u2009118 cost saving per QALY lost, with a 79% probability that SWL would be considered cost\u2010effective at a WTP threshold for 1 QALY of \u00a330\u2009000 and 98% at a WTP threshold of \u00a320\u2009000. Decision\u2010makers need to determine if costs saved justify the loss in QALYs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15862","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T22:59:29Z","timestamp":1659135569000},"page":"253-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cost\u2212utility analysis of shockwave lithotripsy vs ureteroscopic stone treatment in adults"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3450-4536","authenticated-orcid":false,"given":"Mary M.","family":"Kilonzo","sequence":"first","affiliation":[{"name":"Health Economics Research Unit University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranan","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Department of Urology Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Thomas","sequence":"additional","affiliation":[{"name":"Centre for Healthcare Randomised Trials University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna","family":"Aucott","sequence":"additional","affiliation":[{"name":"Health Services Research Unit University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"MacLennan","sequence":"additional","affiliation":[{"name":"Academic Urology Unit University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Boon L.","family":"Lam","sequence":"additional","affiliation":[{"name":"NHS Grampian, Department of Urology Aberdeen Royal Infirmary  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Anson","sequence":"additional","affiliation":[{"name":"Department of Urology St Georges University Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Cameron","sequence":"additional","affiliation":[{"name":"Centre for Healthcare Randomised Trials University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kath","family":"Starr","sequence":"additional","affiliation":[{"name":"Warwick Clinical Trials Unit University of Warwick  Warwick UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Urology Norfolk and Norwich University Hospitals NHS Foundation Trust  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis Xavier","family":"Keeley","sequence":"additional","affiliation":[{"name":"Bristol Urological Institute  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles T.","family":"Clark","sequence":"additional","affiliation":[{"name":"BAUS Section\u2009of Endourology Consumer\/Patient Advisory Group  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"N'Dow","sequence":"additional","affiliation":[{"name":"NHS Grampian, Department of Urology Aberdeen Royal Infirmary  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"MacLennan","sequence":"additional","affiliation":[{"name":"Centre for Healthcare Randomised Trials University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"McClinton","sequence":"additional","affiliation":[{"name":"NHS Grampian, Department of Urology Aberdeen Royal Infirmary  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13520"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10495.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-016-0647-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta19630"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e5499"},{"issue":"5","key":"e_1_2_6_7_1","article-title":"Extracorporeal shock wave lithotripsy (ESWL) versus ureteroscopic management for ureteric calculi","author":"Aboumarzouk OM","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.04.016"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.02.044"},{"key":"e_1_2_6_10_1","unstructured":"National Institute for Health and Care Excellence (NICE).Guide to the methods of technology appraisal 2013. 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