{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:39:42Z","timestamp":1787315982113,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T00:00:00Z","timestamp":1662854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the proportion of clinically significant (cs) prostate cancer (PCa) found during follow\u2010up in patients with negative systematic biopsy (SB) followed by non\u2010suspicious multiparametric magnetic resonance imaging (mpMRI) and persistent clinical suspicion of PCa compared to the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A prospective study in a subgroup of patients from a multicentre randomized controlled trial was conducted between 2014 and 2017, including 665 men with prior negative SB with a persistent elevated prostate\u2010specific antigen and\/or suspicious digital rectal examination undergoing mpMRI. All patients with negative SB and Prostate Imaging\u2010Reporting and Data System (PI\u2010RADS) \u22642 on mpMRI entered biochemical follow\u2010up. Follow\u2010up data until December 2021 were collected by reviewing institutional hospital records and the Dutch Pathology Registry (PALGA). The primary outcome was the observed number of csPCa (Gleason \u22653 + 4\/International Society of Urological Pathology grade group \u22652) cases during follow\u2010up compared to the expected number in the general population (standardized incidence ratio [SIR]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 431 patients had non\u2010suspicious mpMRI and entered biochemical follow\u2010up. After a median (interquartile range) follow\u2010up of 41\u2009(23\u201357) months, 38 patients were diagnosed with PCa, of whom 13 (3.0%) had csPCa. The SIR for csPCa was 4.3 (95% confidence interval 2.3\u20137.4; total excess of eight cases). A higher risk of a positive biopsy for (cs)PCa based on the European Randomized Study of Screening for Prostate Cancer risk calculator and a suspicious repeat MRI (PI\u2010RADS \u22653) were significant predictive factors for csPCa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>After negative prior biopsy and non\u2010suspicious mpMRI the risk of csPCa is low. However, compared to the general population, the risk of csPCa is increased despite the high negative predictive value of mpMRI. More research focusing on biochemical and image\u2010guided risk\u2010adapted diagnostic surveillance strategies is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15876","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T08:20:53Z","timestamp":1661156453000},"page":"313-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Incidence of significant prostate cancer after negative\n                    <scp>MRI<\/scp>\n                    and systematic biopsy in the\n                    <scp>FUTURE<\/scp>\n                    trial"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3229-0789","authenticated-orcid":false,"given":"Leonie","family":"Exterkate","sequence":"first","affiliation":[{"name":"Department of Urology Canisius\u2010Wilhelmina Hospital  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Wegelin","sequence":"additional","affiliation":[{"name":"Department of Urology St. Antonius Hospital  Nieuwegein\/Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelle O.","family":"Barentsz","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboudumc  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marloes G.","family":"van der Leest","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboudumc  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alain","family":"Kummer","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Antonius Hospital  Nieuwegein\/Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Vreuls","sequence":"additional","affiliation":[{"name":"Department of Pathology Canisius\u2010Wilhelmina Hospital  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"de Bruin","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Antonius Hospital  Nieuwegein\/Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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