{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:06:58Z","timestamp":1793196418918,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To provide a summary and discussion of international guidelines, position statements and consensus statements in relation to focal therapy (FT) for prostate cancer (PCa).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The European Association of Urology\u2010European Association of Nuclear Medicine\u2010European Society for Radiotherapy and Oncology\u2010European Society of Urogential Radiology\u2010International Society of Urological Pathology\u2010International Society of Geriatric Oncology and American Urological Association\u2010American Society for Radiation Oncology\u2010Society of Urologic Oncology guidelines were interrogated for recommendations for FT. PubMed and Ovid Medline were searched for consensus statements. Only studies in English since 2015 were included. Reference lists of the included articles were also interrogated and a manual search for studies was also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results showed a lack of long\u2010term randomised data for FT. International Urological guidelines emphasised the need for more high\u2010quality clinical trials with robust oncological and toxicity outcomes. Consensus and positions statements were heterogenous.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A globally accepted guideline for FT planning, technique and follow\u2010up are still yet to be determined. Well\u2010designed studies with long\u2010term follow\u2010up and robust clinical and toxicity endpoints are needed to improve our understanding of FT and create uniform guidelines to streamline management and follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15883","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T16:56:28Z","timestamp":1662742588000},"page":"20-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Guidelines of guidelines: focal therapy for prostate cancer, is it time for consensus?"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1117-2409","authenticated-orcid":false,"given":"Sean","family":"Ong","sequence":"first","affiliation":[{"name":"EJ Whitten Foundation Prostate Cancer Research Centre Epworth HealthCare  Melbourne Vic. 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Yaxley","sequence":"additional","affiliation":[{"name":"The University of Queensland School of Medicine  Brisbane QLD Australia"},{"name":"Wesley Urology Clinic Wesley Hospital  Brisbane QLD Australia"},{"name":"Department of Urology Royal Brisbane and Women's Hospital  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs J.","family":"Scheltema","sequence":"additional","affiliation":[{"name":"St. Vincent's Prostate Cancer Research Centre  Darlinghurst NSW Australia"},{"name":"Department of Urology St Vincents Hospital and Campus  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0934-0656","authenticated-orcid":false,"given":"Phillip","family":"Stricker","sequence":"additional","affiliation":[{"name":"St. Vincent's Prostate Cancer Research Centre  Darlinghurst NSW Australia"},{"name":"Department of Urology St Vincents Hospital and Campus  Sydney NSW Australia"},{"name":"Garvan Institute of Medical Research  Darlinghurst NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kae Jack","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Urology Singapore General Hospital  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8553-5618","authenticated-orcid":false,"given":"Nathan","family":"Lawrentschuk","sequence":"additional","affiliation":[{"name":"EJ Whitten Foundation Prostate Cancer Research Centre Epworth HealthCare  Melbourne Vic. Australia"},{"name":"Department of Surgery University of Melbourne  Melbourne Vic. Australia"},{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre  Melbourne Vic. Australia"},{"name":"Department of Urology Royal Melbourne Hospital  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2020.12.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.01.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.09.042"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.11.095"},{"key":"e_1_2_9_6_1","unstructured":"Edward SchaefferSS AntonarakisES ArmstrongAJet\u00a0al.NCCN clinical practice guidelines in oncology (NCCN Guidelines\u00ae) prostate cancer2022. Version 4.2022:[1\u2013197 pp.].2022. 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