{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:14:57Z","timestamp":1774548897076,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To identify whether synchronous reading of multiparametric magnetic resonance imaging (mpMRI) and\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010PSMA\u201011 positron emission tomography (PET)\/computed tomography (prostate\u2010specific membrane antigen [PSMA\u2010PET]) images can improve diagnostic performance and certainty compared with mpMRI\/PSMA\u2010PET reported independently and synthesized, while also assessing concordance between imaging modalities and agreement with histopathology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective analysis of 100 patients randomly selected from the PRIMARY trial, a prospective Phase II multicentre imaging trial. Three dual\u2010trained radiologist\/nuclear medicine physicians re\u2010reported the mpMRI and PSMA\u2010PET both independently and synchronously for the same patients in random order, blinded to previous results. Diagnostic performance was assessed for mpMRI\/PSMA\u2010PET images read synchronously or independently and then synthesized. Agreement between imaging results and histopathology was examined. \u2018Concordance\u2019 between imaging modalities was defined as overlapping lesions. Reporting certainty was evaluated by the individual reporters for each modality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>International Society of Urological Pathology Grade Group \u22652 cancer was present in 60% of patients on biopsy. Synchronous reading of mpMRI\/PSMA\u2010PET increased sensitivity compared to mpMRI or PSMA\u2010PET alone (93% vs 80% vs 88%, respectively), although specificity was not improved (63% vs 58% vs 78%, respectively). No significant difference in diagnostic performance was noted between mpMRI\/PSMA\u2010PET read synchronously and mpMRI or PSMA\u2010PET reported independently and then synthesized. Most patients had concordant imaging (60%), while others had discordant lesions only (28%) or a mixture (concordant and discordant lesions; 12%). When mpMRI\/PSMA\u2010PET findings were concordant and positive, 95% of patients had clinically significant prostate cancer (csPCa). When PSMA\u2010PET alone was compared to synchronous PSMA\u2010PET\/MRI reads, there was an improvement in reader certainty in 20% of scans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Synchronous mpMRI\/PSMA\u2010PET reading improves reader certainty and sensitivity for csPCa compared to mpMRI or PSMA\u2010PET alone. However, synthesizing the results of independently read PSMA\u2010PET and mpMRI reports provided similar diagnostic performance to synchronous PSMA\u2010PET\/MRI reads. This may provide greater flexibility for urologists in terms of referral patterns, reducing healthcare system costs and improving efficiencies in prostate cancer diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15929","type":"journal-article","created":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T04:39:01Z","timestamp":1668314341000},"page":"588-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Synchronous vs independent reading of prostate\u2010specific membrane antigen positron emission tomography (\n                    <scp>PSMA\u2010PET)<\/scp>\n                    and magnetic resonance imaging (\n                    <scp>MRI)<\/scp>\n                    to improve diagnosis of prostate cancer"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4946-7982","authenticated-orcid":false,"given":"Paul","family":"Doan","sequence":"first","affiliation":[{"name":"Garvan Institute of Medical Research  Sydney NSW Australia"},{"name":"St. Vincent's Prostate Cancer Research Centre  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Counter","sequence":"additional","affiliation":[{"name":"Department of Theranostics and Nuclear Medicine St. Vincent's Hospital Sydney  Darlinghurst NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Papa","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Clayton Vic. 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