{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:50:49Z","timestamp":1788587449478,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the clinico\u2010pathological characteristics of non\u2010muscle\u2010invasive bladder cancer (NMIBC) treated in metropolitan France over 1\u2009year when bacille Calmette\u2010Gu\u00e9rin (BCG) was subject to a national quota, and to document, in the context of recurrent shortages of intravesical BCG for NMIBC, the real\u2010life indications for adjuvant treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Between February 2021 and February 2022, the French National Agency for the Safety of Medicines (ANSM) asked the French Association of Urology to propose a science\u2010based quota solution for BCG using a clinical score. The ANSM then asked the distributor of the drug, MEDAC, to collect the scores for all patients for whom BCG was requested by healthcare institutions and to prioritize the requests for patients with the highest scores. Tumour stage, grade, size, number, time to recurrence, carcinoma\n                      <jats:italic>in\u00a0situ<\/jats:italic>\n                      , age, accessibility of alternative treatments (total cystectomy, radio\u2010chemotherapy, thermo\u2010chemotherapy) and BCG treatment progress (initiation or maintenance) were documented for each intravesical BCG prescription. A descriptive analysis of the data collected during the quota year was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the 1\u2010year quota, 25\u2009878 requests for BCG were made for 19\u2009024 patients, 60.5% of whom were aged \u226570\u2009years. Requests for induction and maintenance treatment accounted for 12\u2009704 (49.1%) and 13\u2009174 prescriptions (50.9%), respectively. NMIBC treated with BCG maintenance therapy was more frequently high\u2010risk NMIBC (91.7% vs 90.2%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u20090.0001) than NMIBC for which induction therapy was requested. The number of cases of NMIBC leading to BCG adjuvant treatment was estimated at 12\u2009704 cases\/66\u2009062\u2009188 inhabitants over 1\u2009year in metropolitan France.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data suggest that the incidence of NMIBC at high risk of recurrence and progression is underestimated in reference epidemiological studies. These results should help to better define future care needs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15941","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T11:49:22Z","timestamp":1670068162000},"page":"611-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A prospective descriptive 1\u2010year study in France of all\n                    <scp>BCG<\/scp>\n                    therapy dispensations for\n                    <scp>non\u2010muscle\u2010invasive bladder cancer<\/scp>"],"prefix":"10.1111","volume":"131","author":[{"given":"Yann","family":"Neuzillet","sequence":"first","affiliation":[{"name":"Service d'Urologie, H\u00f4pital Foch Universit\u00e9 Paris Saclay  Suresnes 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