{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:25:32Z","timestamp":1777879532617,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016053","name":"Paul Ramsay Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the safety, and short to mid\u2010term oncological and quality\u2010of\u2010life (QoL) outcomes of focal irreversible electroporation (IRE) for radio\u2010recurrent prostate cancer (PCa) at a median follow\u2010up of 4\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This was a single\u2010centre series of men with biopsy\u2010proven radio\u2010recurrent PCa treated with IRE between December 2013 and February 2022, with a minimum follow\u2010up of 6 months. Follow\u2010up included magnetic resonance imaging at 6 months, and standard transperineal saturation template biopsies at 12 months. Further biopsies were guided by suspicion on serial imaging or prostate\u2010specific antigen (PSA) levels. Validated questionnaires were used to measure functional outcomes. Significant local recurrence was defined as any International Society of Urological Pathology (ISUP) score \u2265\u20092 on biopsies. Progression\u2010free survival was defined as no signs of local or systemic disease on either imaging or template biopsies, or according to the Phoenix criteria for biochemical recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Final analysis was performed on 74 men with radio\u2010recurrent PCa (median age 69\u2009years, median PSA level 5.4\u2009ng\/mL, 76% ISUP score 2\/3). The median (range) follow\u2010up was 48 (27\u201368) months. One rectal fistula occurred, and eight patients developed urethral sloughing that resolved with transurethral resection. Among patients who returned questionnaires (30\/74, 41%), 93% (28\/30) had preserved urinary continence and 23% (7\/30) had sustained erectile function at 12\u2010month follow\u2010up. Local control was achieved in 57 patients (77%), who needed no further treatment. Biopsy diagnosed 41(55%) patients received follow up template biopsies, in\u2010field recurrences occurred in 7% (3\/41), and out\u2010field recurrences occurred in 15% of patients (6\/41). The metastasis\u2010free survival rate was 91% (67\/74), with a median (interquartile range) time to metastases of 8 (5\u201327) months. The Kaplan\u2013Meier estimated 5\u2010year progression\u2010free survival rate was 60%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These short\u2010 to mid\u2010term safety, oncological and QoL outcome data endorse results from smaller series and show the ability of salvage focal IRE to safely achieve oncological control in patients with radio\u2010recurrent PCa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15948","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T03:00:42Z","timestamp":1672714842000},"page":"14-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Median 4\u2010year outcomes of salvage irreversible electroporation for localized radio\u2010recurrent prostate cancer"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8137-9299","authenticated-orcid":false,"given":"Bart","family":"Geboers","sequence":"first","affiliation":[{"name":"Garvan Institute of Medical Research &amp; The Kinghorn Cancer Centre  Darlinghurst, Sydney NSW Australia"},{"name":"Department of Urology St. Vincent's Prostate Cancer Research Centre  Darlinghurst, Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthijs J.","family":"Scheltema","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research &amp; The Kinghorn Cancer Centre  Darlinghurst, Sydney NSW Australia"},{"name":"St. Vincent's Clinical School University of New South Wales  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-5509","authenticated-orcid":false,"given":"Alexandar","family":"Blazevski","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research &amp; The Kinghorn Cancer Centre  Darlinghurst, Sydney NSW Australia"},{"name":"Department of Urology St. Vincent's Prostate Cancer Research Centre  Darlinghurst, Sydney NSW Australia"},{"name":"St. Vincent's Clinical School University of New South Wales  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athos","family":"Katelaris","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research &amp; 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The Kinghorn Cancer Centre  Darlinghurst, Sydney NSW Australia"},{"name":"Department of Urology St. Vincent's Prostate Cancer Research Centre  Darlinghurst, Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Barreto","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research &amp; The Kinghorn Cancer Centre  Darlinghurst, Sydney NSW Australia"},{"name":"Department of Urology St. Vincent's Prostate Cancer Research Centre  Darlinghurst, Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayne","family":"Matthews","sequence":"additional","affiliation":[{"name":"Department of Urology St. Vincent's Prostate Cancer Research Centre  Darlinghurst, Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Maree","family":"Haynes","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research &amp; The Kinghorn Cancer Centre  Darlinghurst, Sydney NSW Australia"},{"name":"Department of Urology St. Vincent's Prostate Cancer Research Centre  Darlinghurst, Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warick","family":"Delprado","sequence":"additional","affiliation":[{"name":"Douglass Hanly Moir Pathology  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Shnier","sequence":"additional","affiliation":[{"name":"I\u2010MED Radiology  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5115-9930","authenticated-orcid":false,"given":"James E.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research &amp; 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