{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:08:17Z","timestamp":1785391697710,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["2015\u20101\u2010RT\u201003\u2010UPMC\u20101"],"award-info":[{"award-number":["2015\u20101\u2010RT\u201003\u2010UPMC\u20101"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate different scenarios for the management of early diagnosis of cancer (PCa) in men at high genetic risk, using recently developed blood and urinary molecular biomarkers in combination with clinical information alongside multiparametric magnetic resonance imaging (mpMRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A total of 322 patients with a high genetic risk (familial or personal history of cancers or a predisposing germline variant) were included in this study. The primary outcome was the detection rates of PCa (positive biopsy) or clinically significant PCa (biopsy with International Society of Urological Pathology [ISUP] grade &gt;1). Clinical parameters included age, body mass index, ancestry, and germline mutational status,\u00a0mpMRI, prostate\u2010specific antigen density (PSAD), Prostate Health Index and urinary markers (Prostate Cancer Associated 3, SelectMdx\u2122 and T2:ERG score) were assessed. Sensitivity (Se) and specificity (Sp) for each marker at their recommended cut\u2010off for clinical practice were calculated. Comparison between diagnoses accuracy of each procedure and scenario was computed using mutual information based and direct effect contribution using a supervised Bayesian network approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A mpMRI Prostate Imaging\u2010Reporting and Data System (PI\u2010RADS) score \u22653 showed higher Se than mpMRI PI\u2010RADS score \u22654 for detection of PCa (82% vs 61%) and for the detection of ISUP grade &gt;1 lesions (96% vs 80%). mpMRI PI\u2010RADS score \u22653 performed better than a PSA level of \u22653\u2009ng\/mL (Se 96%, Sp 53% vs Se 91%, Sp 8%) for detection of clinically significant PCa. In case of negative mpMRI results, the supervised Bayesian network approach showed that urinary markers (with the same accuracy for all) and PSAD of \u22650.10\u2009ng\/mL\/mL were the most useful indicators of decision to biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found that screening men at high genetic risk of PCa must be based on mpMRI without pre\u2010screening based on a PSA level of &gt;3\u2009ng\/mL, to avoid missing too many ISUP grade &gt;1 tumours and to significantly reduce the number of unnecessary biopsies. However, urinary markers or a PSAD of \u22650.10\u2009ng\/mL\/mL when mpMRI was negative increased the detection of ISUP grade &gt;1 cancers. We suggest that a baseline mpMRI be discussed for men at high genetic risk from the age of 40\u2009years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15968","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T08:19:09Z","timestamp":1673943549000},"page":"745-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical performance of magnetic resonance imaging\n                    <scp>and<\/scp>\n                    biomarkers for prostate cancer diagnosis in men at high genetic risk"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9912-0533","authenticated-orcid":false,"given":"Olivier","family":"Cussenot","sequence":"first","affiliation":[{"name":"CeRePP  Paris France"},{"name":"GRC 5 Predictive Onco\u2010Urology Sorbonne University, AP\u2010HP Sorbonne University  Paris France"},{"name":"Nuffield Department of Surgical Sciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaele","family":"Renard\u2010Penna","sequence":"additional","affiliation":[{"name":"CeRePP  Paris France"},{"name":"GRC 5 Predictive Onco\u2010Urology Sorbonne University, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Montagne","sequence":"additional","affiliation":[{"name":"GRC 5 Predictive Onco\u2010Urology Sorbonne University, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Ondet","sequence":"additional","affiliation":[{"name":"GRC 5 Predictive Onco\u2010Urology Sorbonne University, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Pilon","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Pathology AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Guechot","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Pathology AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Comperat","sequence":"additional","affiliation":[{"name":"CeRePP  Paris France"},{"name":"GRC 5 Predictive Onco\u2010Urology Sorbonne University, AP\u2010HP Sorbonne University  Paris France"},{"name":"Department of Pathology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddie","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2968-7155","authenticated-orcid":false,"given":"Alastair","family":"Lamb","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9583-6382","authenticated-orcid":false,"given":"Geraldine","family":"Cancel\u2010Tassin","sequence":"additional","affiliation":[{"name":"CeRePP  Paris France"},{"name":"GRC 5 Predictive Onco\u2010Urology Sorbonne University, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24360"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2022.04.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.01.070"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.693684"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22898"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12217"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.8505"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.04.039"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-015-0127-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.11.014"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2018.01.010"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-021-00367-8"},{"key":"e_1_2_9_14_1","unstructured":"National Comprehensive Cancer Network.Prostate Cancer Early Detection (Version 1.2022). 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