{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:48Z","timestamp":1787013948032,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,8]]},"abstract":"\n Objective<\/jats:title>\n To report open\u2010label phase data from a recent randomized controlled trial (RCT), after previous data from that study showed improved penile length and erectile function among post\u2010prostatectomy men treated with Restorex penile traction therapy (RxPTT).<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n An RCT (NCT05244486) was performed to evaluate RxPTT vs no treatment (Tx) for 5\u2009months, which was followed by a 3\u2010month open\u2010label phase. Men were stratified based on as\u2010treated data: Group 1\u2009=\u2009No Tx; Group 2\u2009=\u2009No Tx\u2009\u2192\u2009Tx; Group 3\u2009=\u2009Tx\u2009\u2192\u2009No Tx; Group 4\u2009=\u2009Tx. Assessments included stretched penile length and standardized (International Index of Erectile Function [IIEF]) and non\u2010standardized questionnaires.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 82 men were enrolled (mean age 58.6\u2009years) with 9\u2010month data available in 45 of the men. Baseline characteristics were similar among the cohorts. Comparing Group 1 and Group 4 (respectively), notable differences included: IIEF Erectile Function domain (IIEF\u2010EF) score (\u22128 vs \u22120.5;\n P<\/jats:italic>\n =\u20090.16), penile length (\u22120.1 vs +1.7\u2009cm;\n P<\/jats:italic>\n <\u20090.01), intracavernosal injection use (86% vs 14%;\n P<\/jats:italic>\n <\u20090.01), Sexual Encounter Profile (SEP) Question 2 (50% vs 100%;\n P<\/jats:italic>\n <\u20090.01), SEP Question 3 (33% vs 100%;\n P<\/jats:italic>\n <\u20090.01). Men who crossed over to Tx (Group 2) failed to achieve equivalent improvements in length (+0.5\u2009cm) or sexual function (IIEF\u2010EF score \u22126) compared to men treated early (Groups 3 and 4). Those who crossed over to no treatment after initial treatment (Group 3) experienced preserved length (+1.8\u2009cm), and erectile function (IIEF\u2010EF score +0) despite therapy discontinuation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Use of RxPTT beginning 1 month post\u2010prostatectomy results in improved penile length and erectile function, with benefits maintained after discontinuing therapy. If confirmed, these results represent the first postoperative therapy shown in a RCT to improve erectile function post\u2010prostatectomy. External validation is warranted.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.16033","type":"journal-article","created":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T23:11:50Z","timestamp":1682291510000},"page":"217-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of\n RestoreX<\/scp>\n after prostatectomy: open\u2010label phase of a randomized controlled trial"],"prefix":"10.1111","volume":"132","author":[{"given":"Andrew","family":"Zganjar","sequence":"first","affiliation":[{"name":"Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Toussi","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9974-3936","authenticated-orcid":false,"given":"Matthew","family":"Ziegelmann","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Frank","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Boorjian","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Tollefson","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6842-733X","authenticated-orcid":false,"given":"Landon","family":"Trost","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester MN USA"},{"name":"Male Fertility and Peyronie's Clinic Orem UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2012.13"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07161.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12443"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001792"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.06.083"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.09.051"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2016.09.008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2020.10.022"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000245"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2020.10.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12400"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2019.03.007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443-020-0292-y"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14602"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000154356.76027.4f"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990040506"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071359"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01649-7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12082"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:43:58Z","timestamp":1761749038000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,9]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/bju.16033"],"URL":"https:\/\/doi.org\/10.1111\/bju.16033","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,9]]},"assertion":[{"value":"2023-05-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}