{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:52:31Z","timestamp":1785937951916,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T00:00:00Z","timestamp":1685232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To ascertain whether low\u2010dose tadalafil (5\u2009mg) is more efficient than tamsulosin (0.4\u2009mg) in facilitating calculus expulsion in those receiving extracorporeal shockwave lithotripsy for solitary upper urinary tract calculi.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This was a triple\u2010blinded, prospective, superiority, randomized controlled, single\u2010centre trial. A total of 250 patients with solitary renal or ureteric calculus measuring 6\u201324\u2009mm were randomized (1:1) to receive either 0.4\u2009mg tamsulosin or 5\u2009mg tadalafil daily for 30\u2009days or until calculus clearance, whichever was earlier.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no difference in the primary outcome, namely, calculus expulsion rate at 30\u2009days (tamsulosin vs tadalafil,\n                      <jats:italic>n<\/jats:italic>\n                      (%) 99 [81.1%] vs 98 [80.3%] respectively, 95% confidence interval = 0.8% [\u22129.0, 10.7],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.874). Similarly, a lack of difference was also noted in the secondary outcome, number of days to expulsion (tamsulosin vs tadalafil, geometric mean [SD] 13.59 [2.39] vs 13.74 [2.39] respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.928). Four patients discontinued the drug due to adverse drug reactions in the tadalafil group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low\u2010dose tadalafil is not superior to tamsulosin in improving calculus expulsion when used as an adjunct to shockwave lithotripsy. In this study, we also noted that tadalafil was less tolerated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16038","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T11:59:40Z","timestamp":1683028780000},"page":"314-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is low\u2010dose tadalafil better than tamsulosin? A randomized controlled trial in\n                    <scp>shockwave lithotripsy<\/scp>\n                    for solitary upper tract calculi"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-0096","authenticated-orcid":false,"given":"Madhuri Evangeline","family":"Sadanala","sequence":"first","affiliation":[{"name":"Urology Christian Medical College and Hospital  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6748-1457","authenticated-orcid":false,"given":"Anuj Deep","family":"Dangi","sequence":"additional","affiliation":[{"name":"Urology Christian Medical College and Hospital  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Nursing Services Christian Medical College and Hospital  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonisamy","family":"Balavendra","sequence":"additional","affiliation":[{"name":"Biostatistics Christian Medical College and Hospital  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramanian","family":"Annadurai","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Christian Medical College and Hospital  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv Paul","family":"Mukha","sequence":"additional","affiliation":[{"name":"Urology Christian Medical College and Hospital  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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