{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:36:54Z","timestamp":1784248614765,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report the oncological survival outcomes of men with penile sarcomatoid squamous cell carcinoma (sSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of men with penile sSCC diagnosed between January 2010 and January 2020 in a single centre was conducted. Disease\u2010specific (DSS), recurrence\u2010free (RFS) and metastasis\u2010free (MFS) survival were evaluated. Outcomes were compared with a non\u2010sarcomatoid penile SCC cohort matched to age, type of surgery and tumour stage. Kaplan\u2013Meier plots were used to estimate survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all, 1286 men were diagnosed with penile SCC during the study period and of these 38 (3%) men had sSCC. The median (interquartile range) age and follow\u2010up was 70\u2009(57\u201381)\u2009years and 16\u2009(7\u201344)\u2009months, respectively. Operations performed included: circumcision, one (2.6%); wide local excision, four (10.5%); glansectomy, 11 (29%); partial penectomy, 10 (26%); subtotal\/total penectomy, 12 (32%). The Kaplan\u2013Meier estimated 12\u2010, 24\u2010 and 36\u2010month DSS was 62% (vs non\u2010sarcomatoid, 67%), 43% (vs non\u2010sarcomatoid, 67%) and 36% (vs non\u2010sarcomatoid, 67%), respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03). The Kaplan\u2013Meier estimated 12\u2010 and 24\u2010month RFS was 47% (vs non\u2010sarcomatoid, 60%) and 28% (vs non\u2010sarcomatoid, 55%), respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01). The MFS was 52% (vs non\u2010sarcomatoid, 62%) at 12\u2009months and 37% (vs non\u2010sarcomatoid, 57%) at 24\u2009months (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sarcomatoid differentiation was associated with a lower DSS, RFS and MFS. Due to the rarity of its incidence and aggressiveness, expert histological review and multidisciplinary management is required in a specialist penile cancer centre.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16044","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T22:39:05Z","timestamp":1683844745000},"page":"337-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes of penile sarcomatoid squamous cell carcinoma from a single tertiary referral centre: a matched cohort study"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5703-2319","authenticated-orcid":false,"given":"Karl H.","family":"Pang","sequence":"first","affiliation":[{"name":"Male Genital Cancer Centre, Institute of Andrology University College London Hospitals NHS Foundation Trust  London UK"},{"name":"Division of Surgery and Interventional Science University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedict","family":"Girling","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Osinibi","sequence":"additional","affiliation":[{"name":"Male Genital Cancer Centre, Institute of Andrology University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramvir","family":"Sawhney","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiman","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Histopathology University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Histopathology University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Hadway","sequence":"additional","affiliation":[{"name":"Male Genital Cancer Centre, Institute of Andrology University College London Hospitals NHS Foundation Trust  London UK"},{"name":"Department of Urology Royal Berkshire NHS Foundation Trust  Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Nigam","sequence":"additional","affiliation":[{"name":"Male Genital Cancer Centre, Institute of Andrology University College London Hospitals NHS Foundation Trust  London UK"},{"name":"Department of Urology Royal Surrey NHS Foundation Trust  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowland","family":"Rees","sequence":"additional","affiliation":[{"name":"Male Genital Cancer Centre, Institute of Andrology University College London Hospitals NHS Foundation Trust  London UK"},{"name":"Department of Urology University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2958-1614","authenticated-orcid":false,"given":"Asif","family":"Muneer","sequence":"additional","affiliation":[{"name":"Male Genital Cancer Centre, Institute of Andrology University College London Hospitals NHS Foundation Trust  London UK"},{"name":"NIHR Biomedical Research Centre University College London Hospitals NHS Foundation Trust  London UK"},{"name":"Division of Surgery and Interventional Science University College London  London UK"},{"name":"Department of Surgical Biotechnology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5876-6696","authenticated-orcid":false,"given":"Constantine","family":"Alifrangis","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6364-0310","authenticated-orcid":false,"given":"Hussain M.","family":"Alnajjar","sequence":"additional","affiliation":[{"name":"Male Genital Cancer Centre, Institute of Andrology University College London Hospitals NHS Foundation Trust  London UK"},{"name":"Division of Surgery and Interventional Science University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000160440.46394.a8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14247"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181a418ae"},{"key":"e_1_2_10_6_1","volume-title":"Urinary and Male Genital Tumours: WHO Classification of 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EAU Guidelines.2022[cited 2022 Oct 31]. Available at:https:\/\/uroweb.org\/guidelines\/penile\u2010cancer"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.04.028"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.06.008"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02365"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.01.014"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:30:45Z","timestamp":1761737445000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/bju.16044"],"URL":"https:\/\/doi.org\/10.1111\/bju.16044","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2023-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}