{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:08:42Z","timestamp":1782140922423,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008492","name":"Swiss Continence Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To present the protocol for a randomized controlled trial (RCT) evaluating the efficacy and safety of transcutaneous tibial nerve stimulation (TTNS) for refractory neurogenic lower urinary tract dysfunction (NLUTD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Results<\/jats:title>\n                    <jats:p>bTUNED (bladder and TranscUtaneous tibial Nerve stimulation for nEurogenic lower urinary tract Dysfunction) is an international multicentre, sham\u2010controlled, double\u2010blind RCT investigating the efficacy and safety of TTNS. The primary outcome is success of TTNS, defined as improvements in key bladder diary variables at study end compared to baseline values. The focus of the treatment is defined by the Self\u2010Assessment Goal Achievement (SAGA) questionnaire. Secondary outcomes are the effect of TTNS on urodynamic, neurophysiological, and bowel function outcome measures, as well as the safety of TTNS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A total of 240 patients with refractory NLUTD will be included and randomized 1:1 into the verum or sham TTNS group from March 2020 until August 2026. TTNS will be performed twice a week for 30\u2009min during 6\u2009weeks. The patients will attend baseline assessments, 12 treatment visits and follow\u2010up assessments at the study end.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16081","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T07:54:11Z","timestamp":1684482851000},"page":"343-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>bTUNED<\/scp>\n                    : transcutaneous tibial nerve stimulation for neurogenic lower urinary tract dysfunction"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7914-8264","authenticated-orcid":false,"given":"Stephanie A.","family":"Stalder","sequence":"first","affiliation":[{"name":"Department of Neuro\u2010Urology, Balgrist University Hospital University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3330-5623","authenticated-orcid":false,"given":"Oliver","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology, Balgrist University Hospital University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4350-6816","authenticated-orcid":false,"given":"Collene E.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology, Balgrist University Hospital University of Z\u00fcrich  Z\u00fcrich Switzerland"},{"name":"Swiss Paraplegic Research, Nottwil and Department of Health Sciences and Medicine University of Lucerne  Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-154X","authenticated-orcid":false,"given":"Lucas M.","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Medignition Inc. 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