{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T20:19:59Z","timestamp":1785183599976,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T00:00:00Z","timestamp":1686441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate whether rectus sheath catheter (RSC) insertion may be an alternative to thoracic epidural (TE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>In a non\u2010blinded, single\u2010centre, non\u2010inferiority study, patients undergoing open radical cystectomy were randomized 1:1 to receive either a TE or surgically placed RSC. The primary endpoint was cumulative opiate use (median oral morphine equivalent [OME]) in the first 72\u2009h postoperatively. Secondary outcomes included visual analogue scale pain scores, measures of postoperative recovery including mobility and time to regular diet, and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010seven patients were randomized (51 TE, 46 RSC). The median OME was 103\u2009(77.5\u2013132.5) mg in the TE arm and 161.75\u2009(117.5\u2013187.5) mg in the RSC arm. A Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      \u2010test confirmed non\u2010inferiority of RSC to TE at a threshold of 15\u2009mg OME (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.002). When comparing pain scores for the first three postoperative days, an early difference was observed that favoured the TE group during post\u2010anaesthesia care unit stay, which was lost after postoperative day 1. Patient satisfaction with analgesia on the third postoperative day was similar in the two arms (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.47). There were no statistically significant differences between arms with respect to the other secondary outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The outcomes from this prospective randomized trial demonstrated non\u2010inferiority of RSC insertion compared to TE with respect to 72\u2010h opiate use. Patient satisfaction with pain control on postoperative day 3 was the same for each group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16094","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:54:05Z","timestamp":1685580845000},"page":"554-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A randomized controlled trial investigating rectus sheath catheters following radical cystectomy"],"prefix":"10.1111","volume":"132","author":[{"given":"Edmund C. 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