{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:28:00Z","timestamp":1790087280192,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To perform a systematic review and meta\u2010analysis to evaluate the impact of body mass index (BMI) on oncological (primary) and surgical (secondary) outcomes of patients who underwent nephrectomy, as obesity or high BMI is a known risk factor for renal cell carcinoma (RCC) and predictor of poorer outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Studies were identified from four electronic databases from database inception to 2 June 2021, according to the Preferred Reporting Items for Systematic Review and Meta\u2010analysis statement. The review protocol was registered in the International Prospective Register of Systematic Reviews with the identification number: CRD42021275124.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 18 studies containing 13\u2009865 patients were identified for the final meta\u2010analysis. Regarding oncological outcomes, higher BMI predicted higher overall survival (BMI &gt;25 vs BMI &lt;25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      : hazard ratio [HR] 0.70, 95% confidence interval [CI] 0.58\u20130.85), cancer\u2010specific survival (BMI &gt;25 vs BMI &lt;25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      : HR 0.60, 95% CI 0.50\u20130.73; BMI 25\u201330 vs BMI &lt;25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      : HR 0.46, 95% CI 0.23\u20130.95; BMI &gt;30 vs BMI &lt;25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      : HR 0.50, 95% CI 0.36\u20130.69), and recurrence\u2010free survival rates (BMI &gt;25 vs BMI &lt;25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      : HR 0.72, 95% CI 0.63\u20130.82; BMI 25\u201330 vs BMI &lt;25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      : HR 0.59, 95% CI 0.42\u20130.82). Those with a lower BMI fared better in surgical outcomes, such as operation time and warm ischaemic time, although the absolute difference was minimal and unlikely to be clinically significant. There was no difference between groups for length of hospital stay, intraoperative or postoperative complications, blood transfusion requirements, and conversion to open surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study suggests that a higher BMI is associated with improved long\u2010term oncological survival and similar perioperative outcomes as a lower BMI. More research into the underlying biological and physiological mechanisms will enable better understanding of the effect of BMI, beyond mere association, on post\u2010nephrectomy outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16103","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T09:01:11Z","timestamp":1688461271000},"page":"608-618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The impact of body mass index on oncological and surgical outcomes of patients undergoing nephrectomy: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3274-0102","authenticated-orcid":false,"given":"Chloe S.H.","family":"Ong","sequence":"first","affiliation":[{"name":"Department of Urology, National University Hospital National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5277-7511","authenticated-orcid":false,"given":"Terence Y.X.","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Urology, National University Hospital National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Mok","sequence":"additional","affiliation":[{"name":"S.H. 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