{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:09:29Z","timestamp":1761761369765,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess if estimated glomerular filtration rate (eGFR) can replace measured GFR (mGFR) in partial nephrectomy (PN) trials, using data from a randomised clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We conducted a post hoc analysis of the renal hypothermia trial. Patients underwent mGFR with diethylenetriaminepentaacetic acid (DTPA) plasma clearance preoperatively and 1\u2009year after PN. The eGFR was calculated using the 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD\u2010EPI) creatinine equations incorporating age and sex, with and without race: 2009 eGFRcr(ASR) and 2009 eGFRcr(AS), and the 2021 equation that only incorporates age and sex: 2021 eGFRcr(AS). Performance was evaluated by determining the median bias, precision (interquartile range [IQR] of median bias), and accuracy (percentage of eGFR within 30% of mGFR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 183 patients were included. Pre\u2010 and postoperative median bias and precision were similar between the 2009 eGFRcr(ASR) (\u22120.2 mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      , 95% confidence interval [CI] \u22122.2 to 1.7, IQR 18.8; and \u22122.9, 95% CI \u22125.1 to \u22121.5, IQR 15, respectively) and 2009 eGFRcr(AS) (\u22120.3 mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      , 95% CI \u22122.4 to 1.5, IQR 18.8; and \u22123.0, 95% CI \u22125.7 to \u22121.7, IQR 15.0, respectively). Bias and precision were worse for the 2021 eGFRcr(AS) (\u22128.8\u2009mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      , 95% CI\u00a0\u221210.9 to \u22126.3, IQR 24.7; and \u221212.0, 95% CI \u221215.8 to \u22128.9, IQR 23.5, respectively). Similarly, pre\u2010 and postoperative accuracy was &gt;90% for the 2009 eGFRcr(ASR) and 2009 eGFRcr(AS) equations\n                      <jats:sub>.<\/jats:sub>\n                      Accuracy was 78.6% preoperatively and 66.5% postoperatively for 2021 eGFRcr(AS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 2009 eGFRcr(AS) can accurately estimate GFR in PN trials and could be used instead of mGFR to reduce cost and patient burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16114","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T08:59:02Z","timestamp":1688633942000},"page":"452-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimated glomerular filtration rate from the renal hypothermia trial: clinical implications"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4370-7837","authenticated-orcid":false,"given":"Francis","family":"Lemire","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery The Ottawa Hospital  Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean A.","family":"Fergusson","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute  Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Knoll","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine The Ottawa Hospital  Ottawa ON Canada"},{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute  Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Morash","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery The Ottawa Hospital  Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9286-5965","authenticated-orcid":false,"given":"Luke T.","family":"Lavall\u00e9e","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery The Ottawa Hospital  Ottawa ON Canada"},{"name":"Division of Nephrology, Department of Medicine The Ottawa Hospital  Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjeeta","family":"Mallick","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine The Ottawa Hospital  Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Finelli","sequence":"additional","affiliation":[{"name":"Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre University Health Network and University of Toronto  Toronto 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