{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:28:44Z","timestamp":1775129324089,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170792"],"award-info":[{"award-number":["82170792"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7222234"],"award-info":[{"award-number":["7222234"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the evidence regarding the therapeutic benefits and safety of oral detrusor relaxing agents (DRAs) in treating neurogenic detrusor overactivity (NDO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search was performed on 1 September 2022. Two authors independently reviewed the articles to extract data using a pre\u2010designed form. The meta\u2010analysis was performed following the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses statement. A common\u2010effect or random\u2010effects model was used based on the heterogeneity among studies. Bayesian network meta\u2010analysis (NMA) was further performed to make indirect comparisons of antimuscarinics and mirabegron.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 23 randomised controlled trials (RCTs) comprising 1697 patients were included in our analysis. Compared to placebo, the clinical benefits of oral DRAs, along with more adverse events (AEs), were demonstrated in the treatment of NDO. In the subgroup analysis, antimuscarinics significantly improved both urodynamic and bladder diary outcomes (including urinary incontinence episodes, urinary frequency, and residual volume), with a higher rate of AEs, such as xerostomia. Mirabegron improved some of the parameters and had fewer bothersome side\u2010effects in patients with NDO. The NMA showed that none of the antimuscarinics or mirabegron was superior or inferior to the other.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Detrusor relaxing agents are associated with improved outcomes in patients with NDO and our analysis has added new evidence regarding antimuscarinics. Evidence concerning mirabegron as first\u2010line therapy for NDO is still limited. Well\u2010designed RCTs are still required in this specific population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16142","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T21:09:50Z","timestamp":1690492190000},"page":"25-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Detrusor relaxing agents for neurogenic detrusor overactivity: a systematic review, meta\u2010analysis and network meta\u2010analysis"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7927-1393","authenticated-orcid":false,"given":"Zhonghan","family":"Zhou","sequence":"first","affiliation":[{"name":"Shandong University  Jinan Shandong China"},{"name":"Department of Urology China Rehabilitation Research Center  Beijing China"},{"name":"China Rehabilitation Science Institute  Beijing China"},{"name":"University of Health and Rehabilitation Sciences  Qingdao Shandong China"},{"name":"School of Rehabilitation Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5612-6804","authenticated-orcid":false,"given":"Xuesheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology China Rehabilitation Research Center  Beijing China"},{"name":"China Rehabilitation Science Institute  Beijing China"},{"name":"University of Health and Rehabilitation Sciences  Qingdao Shandong China"},{"name":"School of Rehabilitation Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Neural Injury and Rehabilitation  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology China Rehabilitation Research Center  Beijing China"},{"name":"China Rehabilitation Science Institute  Beijing China"},{"name":"University of Health and Rehabilitation Sciences  Qingdao Shandong China"},{"name":"School of Rehabilitation Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Neural Injury and Rehabilitation  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7092-6576","authenticated-orcid":false,"given":"Limin","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Urology China Rehabilitation Research Center  Beijing China"},{"name":"China Rehabilitation Science Institute  Beijing China"},{"name":"University of Health and Rehabilitation Sciences  Qingdao Shandong China"},{"name":"School of Rehabilitation Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Neural Injury and Rehabilitation  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.phm.0000219229.92056.c2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160818580"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.02.036"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.07.089"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.05.069"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2016.63"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-03040-x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_10_11_1","unstructured":"J H. 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