{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:53:46Z","timestamp":1782215626814,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010CA008748"],"award-info":[{"award-number":["P30\u2010CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the feasibility of a digitally automated population\u2010based programme for organised prostate cancer testing (OPT) in Southern Sweden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A pilot project for a regional OPT was conducted between September 2020 and February 2021, inviting 999 randomly selected men aged 50, 56, or 62\u2009years. Risk stratification was based on prostate\u2010specific antigen (PSA) level, PSA density (PSAD), and bi\u2010parametric prostate magnetic resonance imaging (MRI). Men with a PSA level of 3\u201399\u2009ng\/mL had an MRI, and men with elevated PSA level (\u22653\u2009ng\/mL) had a urological check\u2010up, including a digital rectal examination and transrectal ultrasonography (TRUS). Indications for targeted and\/or systematic transrectal prostate biopsies were suspicious lesions on MRI (Prostate Imaging\u2010Reporting and Data System [PI\u2010RADS]\u20094\u20135) and\/or PSAD\u2009&gt;\u20090.15\u2009ng\/mL\/mL. Additional indications for prostate biopsies were palpable tumours, PSA ratio\u2009&lt;\u20090.1, or cancer suspicion on TRUS. Patient selection, mail correspondence, data collection, and algorithm processing were performed by an automated digital management system. Feasibility is reported descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 418 men had a PSA test (42%), with increasing participation rates by age (50\u2009years, 38%; 56\u2009years, 44%; and 62\u2009years, 45%). Among these, 35 men (8%) had elevated PSA levels (\u22653\u2009ng\/mL: one of 139, aged 50\u2009years; 10\/143, aged 56\u2009years; and 24\/146, aged 62\u2009years). On MRI, 16 men (48%) had a negative scan (PI\u2010RADS\u2009&lt;\u20093), seven men (21%) had PI\u2010RADS\u20093, nine men (27%) had PI\u2010RADS\u20094, and one man (3%) had PI\u2010RADS\u20095. All men with PI\u2010RADS\u20094 or 5 underwent prostate biopsies, as well as two men with PI\u2010RADS\u20093 due to PSAD\u2009&gt;\u20090.15\u2009ng\/mL\/mL or a suspicious finding on TRUS. Prostate cancer was diagnosed in 10 men. Six men underwent active treatment, whereas four men were assigned to active surveillance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our OPT model is feasible from an operational point of view, but due to the limited scale of this study no conclusions can be made regarding the efficacy of the diagnostic model or outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16143","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T13:04:06Z","timestamp":1690808646000},"page":"87-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A pilot study of an organised population\u2010based testing programme for prostate cancer"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1386-580X","authenticated-orcid":false,"given":"Max","family":"Alterbeck","sequence":"first","affiliation":[{"name":"Department of Urology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Division of Urological Cancers, Department of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4663-8520","authenticated-orcid":false,"given":"Erik","family":"Thimansson","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Physiology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Division of Diagnostic Radiology, Department of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Bengtsson","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Physiology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Division of Diagnostic Radiology, Department of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9177-7322","authenticated-orcid":false,"given":"Erik","family":"Baubeta","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Physiology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Division of Diagnostic Radiology, Department of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5678-3882","authenticated-orcid":false,"given":"Sophia","family":"Zackrisson","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Physiology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Division of Diagnostic Radiology, Department of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2963-1119","authenticated-orcid":false,"given":"Anetta","family":"Bolejko","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Physiology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Division of Diagnostic Radiology, Department of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5019-6254","authenticated-orcid":false,"given":"Kevin","family":"Sandeman","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Molecular Diagnostics Medical Services  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3553-5710","authenticated-orcid":false,"given":"Sigrid","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Clinical Sciences Sahlgrenska Academy at University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Surgery (Urology Service) Memorial Sloan Kettering Cancer Center  New York NY USA"},{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jiborn","sequence":"additional","affiliation":[{"name":"Department of Urology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Division of Urological Cancers, Department of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5761-3786","authenticated-orcid":false,"given":"Anders","family":"Bjartell","sequence":"additional","affiliation":[{"name":"Department of Urology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Division of Urological Cancers, Department of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Cause of death statistics","author":"National Board of Health and Welfare","year":"2022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810084"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00348-X"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.12.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2022.06.008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.02.033"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001497"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70146-7"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2209454"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15683"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.20.2695"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.12.006"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011967"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2214122"},{"key":"e_1_2_10_16_1","unstructured":"Sweden Tnpcro.NPCR: The national prostate cancer register of Sweden.2022. Available at:https:\/\/statistik.incanet.se\/npcr\/. Accessed March 2023"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T16:02:26Z","timestamp":1761753746000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,10]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/bju.16143"],"URL":"https:\/\/doi.org\/10.1111\/bju.16143","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,10]]},"assertion":[{"value":"2023-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}