{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:32:25Z","timestamp":1787495545913,"version":"build-2736575974"},"reference-count":68,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine and summarize the available data on urinary, sexual, and health\u2010related quality\u2010of\u2010life (HRQOL) outcomes after traditional radical cystectomy (RC), reproductive organ\u2010preserving RC (ROPRC) and nerve\u2010sparing RC (NSRC) for bladder cancer (BCa) in female patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The PubMed, SCOPUS and Web of Science databases were searched to identify studies reporting functional outcomes in female patients undergoing RC and urinary diversion for the treatment of BCa. The outcomes of interest were voiding function (for orthotopic neobladder [ONB]), sexual function and HRQOL. The following independent variables were derived and included in the meta\u2010analysis: pooled rate of daytime and nighttime continence\/incontinence, and intermittent self\u2010catheterization (ISC) rates. Analyses were performed separately for traditional, organ\u2010 and\/or nerve\u2010sparing surgical approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010three studies comprising 2740 female patients (1201 traditional RC and 1539 organ\u2010\/nerve\u2010sparing RC, and 264 nerve\u2010sparing\u2010alone RC) were eligible for qualitative synthesis; 44 studies comprising 2418 female patients were included in the quantitative synthesis. In women with ONB diversion, the pooled rates of daytime continence after traditional RC, ROPRC and NSRC were 75.2%, 79.3% and 71.2%, respectively. The pooled rate of nighttime continence after traditional RC was 59.5%; this rate increased to 70.7% and 71.7% in women who underwent ROPRC and NSRC, respectively. The pooled rate of ISC after traditional RC with ONB diversion in female patients was 27.6% and decreased to 20.6% and 16.8% in patients undergoing ROPRC and NSRC, respectively. The use of different definitions and questionnaires in the assessment of postoperative sexual and HRQOL outcomes did not allow a systematic comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Female organ\u2010 and nerve\u2010sparing surgical approaches during RC seem to result in improved voiding function. There is a significant need for well\u2010designed studies exploring sexual and HRQOL outcomes to establish evidence\u2010based management strategies to support a shared decision\u2010making process tailored towards patient expectations and satisfaction. Understanding expected functional, sexual and quality\u2010of\u2010life outcomes is necessary to allow individualized pre\u2010 and postoperative counselling and care delivery in female patients planned to undergo RC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16152","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T20:33:31Z","timestamp":1691699611000},"page":"246-258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Urinary function in female patients after traditional, organ\u2010sparing and nerve\u2010sparing radical cystectomy for bladder cancer: a systematic review and pooled analysis"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8953-0272","authenticated-orcid":false,"given":"Ekaterina","family":"Laukhtina","sequence":"first","affiliation":[{"name":"Department of Urology, Comprehensive Cancer Center Medical 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