{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:17:53Z","timestamp":1790698673874,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022896","name":"Australian and New Zealand Urogenital and Prostate Cancer Trials Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022896","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014470","name":"Mundipharma International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014470","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Salvage radiation therapy (SRT) and surveillance for low\u2010risk prostate\u2010specific antigen (PSA) recurrence have competing risks and benefits. The efficacy of early SRT to the prostate bed with or without pelvic lymph nodes compared to surveillance in patients with PSA recurrence after radical prostatectomy and no identifiable recurrent disease evident on prostate specific membrane antigen\u2010positron emission tomography\/computer tomography (PSMA\u2010PET\/CT) is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>The Dedicated Imaging Post\u2010Prostatectomy for Enhanced Radiotherapy outcomes (DIPPER) is an open\u2010label, multicentre, randomised Phase II trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Endpoints<\/jats:title>\n                    <jats:p>The primary endpoint is 3\u2010year event\u2010free survival, with events comprising one of PSA recurrence (PSA \u22650.2\u2009ng\/mL higher than baseline), radiological evidence of metastatic disease, or initiation of systemic or other salvage treatments. Secondary endpoints include patient\u2010reported outcomes, treatment patterns, participant perceptions, and cost\u2010effectiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Eligibility Criteria<\/jats:title>\n                    <jats:p>Eligible participants have PSA recurrence of prostate cancer after radical prostatectomy, defined by serum PSA level of 0.2\u20130.5\u2009ng\/mL, deemed low risk according to modified European Association of Urology biochemical recurrence risk criteria (International Society for Urological Pathology Grade Group \u22642, PSA doubling time &gt;12\u2009months), with no definite\/probable recurrent prostate cancer on PSMA\u2010PET\/CT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A total of 100 participants will be recruited from five Australian centres and randomised 1:1 to SRT or surveillance. Participants will undergo 6\u2010monthly clinical evaluation for up to 36\u2009months. Androgen\u2010deprivation therapy is not permissible. Enrolment commenced May 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>This trial has been registered with the Australian New Zealand Clinical Trials Registry (ACTRN: ACTRN12622001478707).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16158","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T01:56:33Z","timestamp":1692669393000},"page":"39-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Dedicated Imaging Post\u2010Prostatectomy for Enhanced Radiotherapy outcomes (\n                    <scp>DIPPER)<\/scp>\n                    trial protocol: a multicentre, randomised trial of salvage radiotherapy versus surveillance for low\u2010risk biochemical recurrence after radical prostatectomy"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0552-7402","authenticated-orcid":false,"given":"Matthew J.","family":"Roberts","sequence":"first","affiliation":[{"name":"The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)  Camperdown NSW Australia"},{"name":"Royal Brisbane and Women's Hospital  Herston Qld Australia"},{"name":"Redcliffe Hospital  Redcliffe Qld Australia"},{"name":"Faculty of Medicine, Centre for Clinical Research The University of Queensland  Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-4130","authenticated-orcid":false,"given":"Ciara","family":"Conduit","sequence":"additional","affiliation":[{"name":"The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)  Camperdown NSW Australia"},{"name":"Walter and Eliza Hall Institute of Medical Research  Melbourne Vic. Australia"},{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre  Melbourne Vic. Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9066-8244","authenticated-orcid":false,"given":"Ian D.","family":"Davis","sequence":"additional","affiliation":[{"name":"The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)  Camperdown NSW Australia"},{"name":"Department of Medical Oncology Eastern Health  Box Hill Vic. Australia"},{"name":"Monash University Eastern Health Clinical School  Box Hill, Clayton Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"Effeney","sequence":"additional","affiliation":[{"name":"The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)  Camperdown NSW Australia"},{"name":"Royal Brisbane and Women's Hospital  Herston Qld Australia"},{"name":"Redcliffe Hospital  Redcliffe Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1357-0884","authenticated-orcid":false,"given":"Scott","family":"Williams","sequence":"additional","affiliation":[{"name":"The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)  Camperdown NSW Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Vic. Australia"},{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4929-0278","authenticated-orcid":false,"given":"Jarad M.","family":"Martin","sequence":"additional","affiliation":[{"name":"The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)  Camperdown NSW Australia"},{"name":"Department of Radiation Oncology Calvary Mater Newcastle  Newcastle NSW Australia"},{"name":"University of Newcastle  Newcastle NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8622-159X","authenticated-orcid":false,"given":"Michael S.","family":"Hofman","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Vic. Australia"},{"name":"Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence (ProsTIC) Peter MacCallum Centre  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Hruby","sequence":"additional","affiliation":[{"name":"The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)  Camperdown NSW Australia"},{"name":"University of Sydney  Sydney NSW Australia"},{"name":"St Vincent's Clinic  Sydney NSW Australia"},{"name":"Royal North Shore Hospital  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Eapen","sequence":"additional","affiliation":[{"name":"The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)  Camperdown NSW Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Vic. Australia"},{"name":"Olivia Newton\u2010John Cancer Research Institute  Heidelberg Vic. Australia"},{"name":"Austin Hospital  Heidelberg Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0594-9007","authenticated-orcid":false,"given":"Chris","family":"Gianacas","sequence":"additional","affiliation":[{"name":"School of Population Health UNSW Sydney  Sydney NSW Australia"},{"name":"The George Institute for Global Health  Newtown NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3188-1803","authenticated-orcid":false,"given":"Nathan","family":"Papa","sequence":"additional","affiliation":[{"name":"The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)  Camperdown NSW Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5978-8774","authenticated-orcid":false,"given":"Richard De Abreu","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)  Camperdown NSW Australia"},{"name":"Centre for Health Economics Research and Evaluation University of Technology Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4039-5169","authenticated-orcid":false,"given":"Haryana M.","family":"Dhillon","sequence":"additional","affiliation":[{"name":"The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)  Camperdown NSW Australia"},{"name":"Department of Radiation Oncology Calvary Mater Newcastle  Newcastle NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Allen","sequence":"additional","affiliation":[{"name":"The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)  Camperdown NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"Fontela","sequence":"additional","affiliation":[{"name":"The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)  Camperdown NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baldeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health  Newtown NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4895-7384","authenticated-orcid":false,"given":"Louise","family":"Emmett","sequence":"additional","affiliation":[{"name":"The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)  Camperdown NSW Australia"},{"name":"Department of Theranostics and Nuclear Medicine St Vincent's Hospital  Sydney NSW Australia"},{"name":"Garvan Institute of Medical Research  Sydney NSW Australia"},{"name":"University of NSW  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.08.003"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.23.2760"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30456-3"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.04.021"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.10.011"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2019.06.004"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.06.027"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.235028"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.08.002"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.03.016"},{"key":"e_1_2_13_12_1","unstructured":"Australian Government.New Diagnostic Imaging Medicare Benefits Schedule (MBS) items 61563 and 61564.2022. Available at:http:\/\/www.mbsonline.gov.au\/internet\/mbsonline\/publishing.nsf\/Content\/0B1F69A0B341A384CA25880F0080089B\/$File\/Updated%2024%20Jun%202022%20\u2010%20Factsheet\u2010MBS\u2010Items\u201061563\u201061564.18.05.22.pdf. Accessed February 2023"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262821"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262411"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.196683"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171052"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.06.030"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.242180"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15762"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.16086"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.03.010"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2016.1150607"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50207"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.07.030"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-015-0424-4"},{"key":"e_1_2_13_26_1","unstructured":"Psycho\u2010oncology Co\u2010operative Research Group.PRO CoMiDa Form 2012 6 September 2012. Version 2. Available at:https:\/\/www.pocog.org.au\/docview.aspx?id=215. Accessed August 2022"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-026712"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.9607"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-017-0582-5"},{"key":"e_1_2_13_30_1","unstructured":"National Comprehensive Cancer Network.Prostate cancer version 4.2022.2022. Available at:https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/prostate.pdf. Accessed August 2022"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01790-6"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.10.009"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-5200-1"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:20:54Z","timestamp":1761740454000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,14]]},"references-count":32,"journal-issue":{"issue":"S3","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/bju.16158"],"URL":"https:\/\/doi.org\/10.1111\/bju.16158","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,14]]},"assertion":[{"value":"2023-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}