{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:19:46Z","timestamp":1792887586729,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the pressure range generated in the human renal collecting system during ureteroscopy (URS), in a large patient sample, and to investigate a relationship between intrarenal pressure (IRP) and outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      A prospective multi\u2010institutional study was conducted, with ethics board approval; February 2022\u2013March 2023. Recruitment was of 120 consecutive consenting adult patients undergoing semi\u2010rigid URS and\/or flexible ureterorenoscopy (FURS) for urolithiasis or diagnostic purposes. Retrograde, fluoroscopy\u2010guided insertion of a 0.036\u2010cm (0.014\u2033) pressure guidewire (COMET\u2122 II, Boston Scientific, Marlborough, MA, USA) to the renal pelvis was performed. Baseline and continuous ureteroscopic IRP was recorded, alongside relevant operative variables. A 30\u2010day follow\u2010up was completed. Descriptive statistics were applied to IRP traces, with mean (\n                      <jats:sc>sd<\/jats:sc>\n                      ) and maximum values and variance reported. Relationships between IRP and technical variables, and IRP and clinical outcome were interrogated using the chi\u2010square test and independent samples\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 430 pressure traces were analysed from 120 patient episodes. The mean (\n                      <jats:sc>sd<\/jats:sc>\n                      ) baseline IRP was 16.45\u2009(5.99)\u2009mmHg and the intraoperative IRP varied by technique. The mean (\n                      <jats:sc>sd<\/jats:sc>\n                      ) IRP during semi\u2010rigid URS with gravity irrigation was 34.93\u2009(11.66)\u2009mmHg. FURS resulted in variable IRP values: from a mean (\n                      <jats:sc>sd<\/jats:sc>\n                      ) of 26.78\u2009(5.84)\u2009mmHg (gravity irrigation; 12\/14\u2010F ureteric access sheath [UAS]) to 87.27\u2009(66.85)\u2009mmHg (200\u2009mmHg pressurised\u2010bag irrigation; 11\/13\u2010F UAS). The highest single pressure peak was 334.2\u2009mmHg, during retrograde pyelography. Six patients (5%) developed postoperative urosepsis; these patients had significantly higher IRPs during FURS (mean [\n                      <jats:sc>sd<\/jats:sc>\n                      ] 81.7\u2009[49.52]\u2009mmHg) than controls (38.53\u2009[22.6]\u2009mmHg;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A dynamic IRP profile is observed during human in vivo URS, with IRP frequently exceeding expected thresholds. A relationship appears to exist between elevated IRP and postoperative urosepsis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16169","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T10:17:43Z","timestamp":1693563463000},"page":"531-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["In vivo ureteroscopic intrarenal pressures and clinical\u00a0outcomes: a multi\u2010institutional analysis of 120\u00a0consecutive patients"],"prefix":"10.1111","volume":"132","author":[{"given":"Stefanie M.","family":"Croghan","sequence":"first","affiliation":[{"name":"Royal College of Surgeons Ireland (Strategic Academic Recruitment (StAR) Programme)  Dublin Ireland"},{"name":"Department of Urology Blackrock Clinic  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoghan M.","family":"Cunnane","sequence":"additional","affiliation":[{"name":"School of Engineering University of Limerick  Limerick Ireland"},{"name":"Bernal Institute University of Limerick  Limerick Ireland"},{"name":"Health Research Institute University of Limerick  Limerick Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2502-5450","authenticated-orcid":false,"given":"Sorcha","family":"O'Meara","sequence":"additional","affiliation":[{"name":"Royal College of Surgeons Ireland (Strategic Academic Recruitment (StAR) Programme)  Dublin Ireland"},{"name":"Department of Urology Blackrock Clinic  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muheilan","family":"Muheilan","sequence":"additional","affiliation":[{"name":"Department of Urology Tallaght University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor V.","family":"Cunnane","sequence":"additional","affiliation":[{"name":"School of Engineering University of Limerick  Limerick Ireland"},{"name":"Bernal Institute University of Limerick  Limerick Ireland"},{"name":"Health Research Institute University of Limerick  Limerick Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Patterson","sequence":"additional","affiliation":[{"name":"Department of Urology and Transplantation Beaumont Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Skolarikos","sequence":"additional","affiliation":[{"name":"European Association of Urology (EAU) Urolithiasis Guidelines Panel  Arnhem The Netherlands"},{"name":"2nd Department of Urology National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6248-6478","authenticated-orcid":false,"given":"Bhaskar","family":"Somani","sequence":"additional","affiliation":[{"name":"European Association of Urology (EAU) Urolithiasis Guidelines Panel  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T.","family":"Walsh","sequence":"additional","affiliation":[{"name":"School of Engineering University of Limerick  Limerick Ireland"},{"name":"Bernal Institute University of Limerick  Limerick Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rustom P.","family":"Manecksha","sequence":"additional","affiliation":[{"name":"Department of Urology Tallaght University Hospital  Dublin Ireland"},{"name":"Department of Surgery Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry B.","family":"McGuire","sequence":"additional","affiliation":[{"name":"Department of Urology St. Michael's Hospital  Dublin Ireland"},{"name":"Department of Urology St. Vincent's University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall F.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Urology Blackrock Clinic  Dublin Ireland"},{"name":"Department of Urology 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