{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:48Z","timestamp":1787013948181,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the additional value of prostate\u2010specific membrane antigen positron emission tomography (PSMA\u2010PET) to conventional diagnostic tools to select patients for hemi\u2010ablative focal therapy (FT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We performed a retrospective analysis on a multicentre cohort (private and institutional) of 138 patients who underwent multiparametric magnetic resonance imaging (mpMRI), PSMA\u2010PET, and systematic biopsies prior to radical prostatectomy between January 2011 and July 2021. Patients were eligible when they met the consensus criteria for FT: PSA &lt;15\u2009ng\/mL, clinical\/radiological T stage \u2264T2b, and International Society of Urological Pathology (ISUP) grade 2\u20133. Clinically significant prostate cancer (csPCa) was defined as ISUP grade\u2009\u22652, extracapsular extension &gt;0.5\u2009mm or seminal vesicle involvement at final histopathology. The diagnostic accuracy of mpMRI, systematic biopsies and PSMA\u2010PET for csPCa (separate and combined) was calculated within a four\u2010quadrant prostate model by receiver\u2010operating characteristic and 2 \u00d7\u20092 contingency analysis. Additionally, we assessed whether the diagnostic tools correctly identified patients suitable for hemi\u2010ablative FT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total 552 prostate quadrants were analysed and 272 (49%) contained csPCa on final histopathology. The area under the curve, sensitivity, specificity, positive predictive value and negative predictive value for csPCa were 0.79, 75%, 83%, 81% and 77%, respectively, for combined mpMRI and systematic biopsies, and improved after addition of PSMA\u2010PET to 0.84, 87%, 80%, 81% and 86%, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u20090.001). On final histopathology 46\/138 patients (33%) were not suitable for hemi\u2010ablative FT. Addition of PSMA\u2010PET correctly identified 26\/46 (57%) non\u2010suitable patients and resulted in 4\/138 (3%) false\u2010positive exclusions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Addition of PSMA\u2010PET to the conventional work\u2010up\u00a0by mpMRI and systematic biopsies could improve selection for hemi\u2010ablative FT and guide exclusion of patients for whom whole\u2010gland treatments might be a more suitable treatment option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16207","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:30:48Z","timestamp":1697761848000},"page":"14-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prostate\u2010specific membrane antigen positron emission tomography in addition to multiparametric magnetic resonance imaging and biopsies to select prostate cancer patients for focal therapy"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8137-9299","authenticated-orcid":false,"given":"Bart","family":"Geboers","sequence":"first","affiliation":[{"name":"Garvan Institute of Medical Research &amp; The Kinghorn Cancer Centre  Sydney NSW Australia"},{"name":"St. Vincent's Prostate Cancer Research Centre  Sydney NSW Australia"},{"name":"Department of Radiology and Nuclear Medicine Amsterdam UMC (location VUmc)  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8298-575X","authenticated-orcid":false,"given":"Dennie","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Urology Amsterdam UMC (location VUmc)  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Counter","sequence":"additional","affiliation":[{"name":"Department of Theranostics and Nuclear Medicine St. Vincent's Hospital  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-5509","authenticated-orcid":false,"given":"Alexandar","family":"Blazevski","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research &amp; The Kinghorn Cancer Centre  Sydney NSW Australia"},{"name":"St. Vincent's Prostate Cancer Research Centre  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5115-9930","authenticated-orcid":false,"given":"James","family":"Thompson","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research &amp; The Kinghorn Cancer Centre  Sydney NSW Australia"},{"name":"St. Vincent's Prostate Cancer Research Centre  Sydney NSW Australia"},{"name":"Department of Urology St. George Hospital  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4946-7982","authenticated-orcid":false,"given":"Paul","family":"Doan","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research &amp; The Kinghorn Cancer Centre  Sydney NSW Australia"},{"name":"St. Vincent's Prostate Cancer Research Centre  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Gondoputro","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research &amp; The Kinghorn Cancer Centre  Sydney NSW Australia"},{"name":"St. Vincent's Prostate Cancer Research Centre  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athos","family":"Katelaris","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research &amp; The Kinghorn Cancer Centre  Sydney NSW Australia"},{"name":"St. Vincent's Prostate Cancer Research Centre  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Maree","family":"Haynes","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research &amp; The Kinghorn Cancer Centre  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warick","family":"Delprado","sequence":"additional","affiliation":[{"name":"Douglas Hanly Moir Pathology  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Department of Urology St. Vincent's Hospital and Private Clinic  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Yuen","sequence":"additional","affiliation":[{"name":"Department of Urology St. Vincent's Hospital and Private Clinic  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre N.","family":"Vis","sequence":"additional","affiliation":[{"name":"Department of Urology Amsterdam UMC (location VUmc)  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim J.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Urology Antoni van Leeuwenhoek \u2013 Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Theranostics and Nuclear Medicine St. Vincent's Hospital  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Theranostics and Nuclear Medicine St. Vincent's Hospital  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Theranostics and Nuclear Medicine St. Vincent's Hospital  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten L.","family":"Donswijk","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Antoni van Leeuwenhoek \u2013 Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Oprea\u2010Lager","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Amsterdam UMC (location VUmc)  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9098-9574","authenticated-orcid":false,"given":"Matthijs J.","family":"Scheltema","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research &amp; 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