{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:27:47Z","timestamp":1790803667499,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the oncological and functional outcomes of focal high\u2010intensity focused ultrasound (HIFU) in treating localised prostate cancer (PCa), a 3\u2010year prospective study was undertaken using periodic post\u2010ablation saturation biopsies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Men with two or fewer lesions of grade group (GG) \u22643 PCa were eligible for participation. Additional criteria included a prostate\u2010specific antigen (PSA) level of \u226415\u2009ng\/mL, clinical T1c\u2010T2, and a life expectancy of \u226510\u2009years. The primary endpoint was failure\u2010free survival (FFS), defined as absence of clinically significant PCa (csPCa) in\u2010 or out\u2010of\u2010field on protocol\u2010mandated saturation biopsy, no whole\u2010gland or systemic salvage treatment, PCa metastasis, or PCa\u2010related death. Results are reported using two distinct definitions of csPCa: (i) the presence of any GG \u22652 and (ii) any GG \u22653 or core involvement of \u22656\u2009mm. Secondary endpoints were functional patient\u2010reported outcome measures addressing urinary, sexual, and bowel function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 91 patients were included: six (7%) with GG1 and 85 (93%) with GG \u22652. In all, 83 (91%) underwent at least one follow\u2010up biopsy. Biopsy attendance at 6, 12, and 36\u2009months was 84%, 67%, and 51%, respectively. The FFS at these time points for any GG \u22652 PCa was 79% (95% confidence interval [CI] 80\u201388%), 57% (95% CI 48\u201369%) and 44% (95% CI 34\u201356%), respectively. Using the second definition, FFS were 88% (95% CI 81\u201395%), 70% (95% CI 61\u201381%) and 65% (95% CI 55\u201377%), respectively. The 3\u2010year cancer\u2010specific survival was 100%, and freedom from metastasis was 99%. Magnetic resonance imaging (MRI) (negative predictive value of up to 89%, 95% CI 84\u201393%) and relative decrease of PSA values (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.4) performed poorly in detecting residual disease. Urinary and bowel assessment returned to baseline questionnaire scores within 3\u2009months. In all, 17 (21%) patients reported meaningful worsening in erectile function. A significant decrease of PCa related anxiety was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Focal HIFU treatment for localised PCa shows excellent functional outcomes with half of the patients remaining cancer\u2010free after 3\u2009years. Whole\u2010gland treatment was avoided in 81%. Early follow\u2010up biopsies are crucial to change or continue the treatment modality at the right time, while the use of MRI and PSA in detecting PCa recurrence is uncertain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16213","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:16:08Z","timestamp":1698452168000},"page":"413-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Focal therapy with\n                    <scp>high\u2010intensity<\/scp>\n                    focused ultrasound for prostate cancer: 3\u2010year outcomes from a prospective trial"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6965-449X","authenticated-orcid":false,"given":"Basil","family":"Kaufmann","sequence":"first","affiliation":[{"name":"Department of Urology University Hospital of Zurich  Zurich Switzerland"},{"name":"Milton and Carroll Petrie Department of Urology Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Raess","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0862-5027","authenticated-orcid":false,"given":"Florian A.","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7339-1458","authenticated-orcid":false,"given":"Uwe","family":"Bieri","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5544-1063","authenticated-orcid":false,"given":"Thomas P.","family":"Scherer","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7375-5357","authenticated-orcid":false,"given":"Moustafa","family":"Elleisy","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivio F.","family":"Donati","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology University Hospital of Zurich  Zurich Switzerland"},{"name":"Radiology Hirslanden Zurich Octorad AG  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels J.","family":"Rupp","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Pathology University Hospital of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Moch","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Pathology University Hospital of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8315-6603","authenticated-orcid":false,"given":"Michael A.","family":"Gorin","sequence":"additional","affiliation":[{"name":"Milton and Carroll Petrie Department of Urology Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-2659","authenticated-orcid":false,"given":"Ashkan","family":"Mortezavi","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8866-8010","authenticated-orcid":false,"given":"Daniel","family":"Eberli","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.02.029"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa074311"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.09.042"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.08.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.03.034"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr0905562"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2010.16"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.08.005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.11.079"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70121-3"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.11.057"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000000053"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000298"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.02.033"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.02.067"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24286"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.5114\/jcb.2011.23203"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.06.1126"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2020.05.010"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32401-1"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00858-X"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36966-5"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00238-0"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11386"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/26.4.404"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2677"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2021.04.059"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000506"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2022.10.006"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2022.07.017"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3894-x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prnil.2022.12.004"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2023.04.007"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2016.07.015"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2021.09.009"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.06.006"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1677-5538.ibju.2019.05.02"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2020.105999"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.5086"},{"key":"e_1_2_10_41_1","unstructured":"PolascikT.International focal therapy outcomes registry: focal therapy society.2023. Available at:https:\/\/focaltherapy.org\/. Accessed September 2023"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.18.1.83"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003341.02"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9056(17)30684-X"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T10:58:22Z","timestamp":1761735502000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,14]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/bju.16213"],"URL":"https:\/\/doi.org\/10.1111\/bju.16213","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,14]]},"assertion":[{"value":"2023-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}