{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:38:24Z","timestamp":1780681104092,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare in a phase III trial the efficacy and safety of nanoparticle albumin\u2010bound (nab)\u2010paclitaxel plus gemcitabine (GA) with that of carboplatin plus gemcitabine (GCb) as a first\u2010line treatment for patients with cisplatin\u2010ineligible metastatic urothelial cancer (mUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Treatment\u2010naive, cisplatin\u2010ineligible patients with mUC were assigned randomly to either the GA (both nab\u2010paclitaxel 125\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and gemcitabine 1000\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      on Days 1 and 8, every 21\u2009days) or GCb group (carboplatin area under the free carboplatin plasma concentration versus time curve of 4.5 on Day 1, gemcitabine 1000\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      on Days 1 and 8, every 21\u2009days). The primary endpoint was progression\u2010free survival (PFS). Secondary endpoints included objective response rate (ORR), disease control rate (DCR), overall survival (OS), safety, and patient\u2010reported outcomes (PROs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The trial was terminated early because of slow accrual after 54 patients were enrolled: 26 in in the GA group and 28 in the GCb groups. The median PFS was 6.7 vs 5.9\u2009months for the GA and GCb groups, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.248). The median OS time was 12.1 vs 10.7\u2009months for the GA and GCb groups, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.837). The ORR and DCR were 40% vs 46.4% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.637) and 72% vs 68% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.188) in the GA and GCb groups, respectively. Patients treated with GA showed significantly lower incidence of Grade 3\u20134 thrombocytopenia and does reduction and delay. Although peripheral sensory neuropathy was higher in the GA arm, no Grade 3 neuropathy occurred. There was no difference in the PROs between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While not powered for comparison, first\u2010line GA showed similar efficacy and better tolerability and might be considered a rational alternative to GCb.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16241","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T17:54:55Z","timestamp":1701107695000},"page":"63-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gemcitabine\/nab\u2010paclitaxel vs gemcitabine\/carboplatin for advanced urothelial carcinoma"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-5511","authenticated-orcid":false,"given":"Xin","family":"An","sequence":"first","affiliation":[{"name":"Department of Medical Oncology State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqian","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Radiology State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen 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