{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T09:01:23Z","timestamp":1776589283301,"version":"3.51.2"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the prognostic ability of lymphovascular invasion (LVI) in upper tract urothelial carcinoma (UTUC) as a predictor of overall survival (OS) using a large North American cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Our cohort included 5940 patients with clinical M0 UTUC who underwent a radical nephroureterectomy (RNU), between 2010 and 2016, within the National Cancer Database. The main variable of interest was LVI status, and its interaction with pathological nodal (pN) status. Kaplan\u2013Meier curves were used to depict the OS also stratifying patients on LVI status. Cox regression analysis tested the impact of LVI status on OS after accounting for the available covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median (interquartile range [IQR]) age at diagnosis was 71\u2009(63\u201378)\u2009years and most patients had pathological T1 stage disease (48.6%). Nodal status was pN0, pN1 and pNx in 45.8%, 6.3% and 47.9%, respectively. Overall, 22.1% had LVI. The median (IQR) follow\u2010up time was 32.6\u2009(16.0\u201353.3)\u2009months. At the 5\u2010year postoperative follow\u2010up, the estimated OS rate was 28% in patients with LVI vs 66% in those without LVI (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). When patients were stratified based on nodal status those rates were 32% vs 68% in pN0 patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), 23% vs 30% in pN1 patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.8), and 28% vs 65% in pNx patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). On multivariable analysis, the presence of LVI was associated with less favourable OS (hazard ratio 1.79, 95% confidence interval 1.60\u20131.99;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study assessed the impact of LVI on OS in patients with UTUC in a large North American nationwide cohort. Our series, as the largest to date, indicate that LVI is associated with less favourable survival outcomes in patients with UTUC after RNU, and this variable could be used in counselling patients about their prognosis and might be a useful tool for future trials to risk\u2010stratify patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16258","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T22:59:22Z","timestamp":1702594762000},"page":"555-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of lymphovascular invasion on survival in surgically treated upper tract urothelial carcinoma: a nationwide analysis"],"prefix":"10.1111","volume":"133","author":[{"given":"Giuseppe Ottone","family":"Cirulli","sequence":"first","affiliation":[{"name":"VUI Center for Outcomes Research, Analysis, and Evaluation Henry Ford Health System  Detroit MI USA"},{"name":"Division of Oncology, Unit of Urology, IRCCS Ospedale San Raffaele Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Corsi","sequence":"additional","affiliation":[{"name":"VUI Center for Outcomes Research, Analysis, and Evaluation Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Rakic","sequence":"additional","affiliation":[{"name":"VUI Center for Outcomes Research, Analysis, and Evaluation Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Stephens","sequence":"additional","affiliation":[{"name":"Public Health Sciences Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Chiarelli","sequence":"additional","affiliation":[{"name":"VUI Center for Outcomes Research, Analysis, and Evaluation Henry Ford Health System  Detroit MI USA"},{"name":"Department of Urology, IRCCS Humanitas Research Hospital Humanitas University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Finati","sequence":"additional","affiliation":[{"name":"VUI Center for Outcomes Research, Analysis, and Evaluation Henry Ford Health System  Detroit MI USA"},{"name":"Department of Urology and Renal Transplantation University of Foggia  Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9976-3638","authenticated-orcid":false,"given":"Matthew","family":"Davis","sequence":"additional","affiliation":[{"name":"VUI Center for Outcomes Research, Analysis, and Evaluation Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane","family":"Tinsley","sequence":"additional","affiliation":[{"name":"VUI Center for Outcomes Research, Analysis, and Evaluation Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshay","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Urology, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00f2","family":"Buffi","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS Humanitas Research Hospital Humanitas University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Lughezzani","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS Humanitas Research Hospital Humanitas University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Carrieri","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation 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