{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:08:24Z","timestamp":1770059304981,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report the incidence of malignancy in gynaecological organs removed during radical cystectomy (RC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A retrospective multicentre study of 1600 RCs at three high\u2010volume institutions between January 2009 and March 2022 was performed. Pathological findings in gynaecological organs in female RC specimens were reviewed. Multivariable logistic regression analyses were used to identify predictors of malignant gynaecological organ involvement (GOI) at time of RC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 302 females with a median (interquartile range) age of 68\u2009(61\u201375)\u2009years underwent RC for clinical (c)Ta\u2013T4 bladder cancer. In all, 56 patients (18.5%) received neoadjuvant chemotherapy. Malignant GOI was seen in 20 patients (6.6%); the most common single sites of GOI were the uterus (five patients) and vaginal wall (four), followed by cervix (one), and ovaries (one). Nine patients had involvement of more than one gynaecological organ. No females had a primary gynaecological malignancy detected incidentally at RC. Patients with GOI were more likely to have cT3\/T4 stage (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), preoperative hydronephrosis (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004), lymphovascular invasion (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002), and squamous cell carcinoma (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005) than those without GOI. On multivariable analysis, cT4 stage was an independent predictor of malignant GOI (odds ratio 88.3, 95% confidence interval 10.1\u20131214;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>To our knowledge, we present the largest multi\u2010institutional study examining malignant GOI in females with bladder cancer undergoing RC. The rate of GOI at the time of RC is low and associated with higher clinical stage. In the absence of clinical or radiological evidence of sexual organ involvement, our results do not support their routine removal at the time of RC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16268","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:48:31Z","timestamp":1702860511000},"page":"474-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Gynaecological organ involvement in females undergoing radical cystectomy: a multicentre study"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6505-8399","authenticated-orcid":false,"given":"Niyati","family":"Lobo","sequence":"first","affiliation":[{"name":"Royal Surrey NHS Foundation Trust  Surrey UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leshanth","family":"Uthayanan","sequence":"additional","affiliation":[{"name":"St George's University Hospitals 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