{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:46:41Z","timestamp":1790412401782,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess whether office\u2010based fulguration (OF) under local anaesthesia for small, recurrent, pathological Ta low\u2010grade (LG) non\u2010muscle\u2010invasive bladder cancer (NMIBC) is an effective alternative to transurethral resection of bladder tumour (TURBT), avoiding the costs and risks of procedure, and anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Of 521 patients with primary TaLG NMIBC, this retrospective study included 270 patients who underwent OF during follow\u2010up for recurrent, small, papillary LG\u2010appearing tumours at a university centre (University Health Network, University of Toronto, Canada). We assessed the cumulative incidence of cancer\u2010specific mortality (CSM) and disease progression (to MIBC or metastases), as well as possible direct cost savings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the 270 patients with recurrent TaLG NMIBC treated with OF, the mean (\n                      <jats:sc>sd<\/jats:sc>\n                      ) age was 64.9\u2009(13.3)\u2009years, 70.8% were men, and 60.3% had single tumours. The mean (\n                      <jats:sc>sd<\/jats:sc>\n                      , range) number of OF procedures per patient was 3.1\u2009(3.2, 1\u201322). The median (interquartile range) follow\u2010up was 10.1\u2009(5.8\u201316.2)\u2009years. Patients also underwent a mean (\n                      <jats:sc>sd<\/jats:sc>\n                      ) of 3.6\u2009(3.0) TURBTs during follow\u2010up in case of numerous or bulkier recurrence. In all, 44.4% of patients never received intravesical therapy. The 10\u2010year incidence of CSM and progression were 0% and 3.1% (95% confidence interval 0.8\u20135.4%), respectively. Direct cost savings in Ontario were estimated at $6994.14 (Canadian dollars) per patient over the study follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study supports that properly selected patients with recurrent, apparent TaLG NMIBC can be safely managed with OF under local anaesthesia with occasional TURBT for larger or numerous recurrent tumours, without compromising long\u2010term oncological outcomes. This approach could generate substantial cost\u2010saving to healthcare systems, is patient\u2010friendly, and could be adopted more widely.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16269","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:54:33Z","timestamp":1702860873000},"page":"289-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Long\u2010term outcomes and cost savings of office fulguration of papillary Ta low\u2010grade bladder cancer"],"prefix":"10.1111","volume":"133","author":[{"given":"Christian","family":"Vitug","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery Mount Sinai Hospital, Sinai Health System  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Lajkosz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0363-5485","authenticated-orcid":false,"given":"Julian","family":"Chavarriaga","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Mount Sinai Hospital, Sinai Health System  Toronto Ontario Canada"},{"name":"Divisions of Urology and Surgical Oncology, Department of Surgery University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2726-4273","authenticated-orcid":false,"given":"Andres","family":"Llano","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Mount Sinai Hospital, Sinai Health System  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Din","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Mount Sinai Hospital, Sinai Health System  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice","family":"Villegas","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Mount Sinai Hospital, Sinai Health System  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Kuk","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Mount Sinai Hospital, Sinai Health System  Toronto Ontario Canada"},{"name":"Divisions of Urology and Surgical Oncology, Department of Surgery University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Mount Sinai Hospital, Sinai Health System  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Gao","sequence":"additional","affiliation":[{"name":"Divisions of Urology and Surgical Oncology, Department of Surgery University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Hemminki","sequence":"additional","affiliation":[{"name":"Divisions of Urology and Surgical Oncology, Department of Surgery University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiral","family":"Kot","sequence":"additional","affiliation":[{"name":"Divisions of Urology and Surgical Oncology, Department of Surgery University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Misurka","sequence":"additional","affiliation":[{"name":"Divisions of Urology and Surgical Oncology, Department of Surgery University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodorus H.","family":"van der Kwast","sequence":"additional","affiliation":[{"name":"Department of Pathology University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Wallis","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Mount Sinai Hospital, Sinai Health System  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7162-5380","authenticated-orcid":false,"given":"Michael A. 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