{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:30:00Z","timestamp":1791811800543,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the prognostic value of T1 substaging in patients treated with bacillus Calmette\u2010Gu\u00e9rin (BCG) or immediate radical cystectomy (iRC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We performed an institutional review board\u2010approved retrospective study analysing non\u2010muscle\u2010invasive bladder cancer (NMIBC) patients with pT1 disease treated with either BCG or iRC between 2000 and 2020. Lamina propria (LP) invasion characteristics were extracted from the pathology report. The Kaplan\u2013Meier method was used to calculate overall survival (OS), cancer\u2010specific survival (CSS) and metastasis\u2010free survival (MFS). Multivariable Cox models were used to determine the association between progression\u2010free survival (PFS) and characteristics in the BCG cohort. A logistic regression model explored the relationship between T1 substaging and upstaging to &gt;pT2 at iRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 411 T1 high\u2010grade patients were identified. LP invasion characteristics were as follows: not specified: 115 (28%); focal\/superficial (F\/S): 147 (35.8%); and extensive\/multifocal (E\/M): 149 (36.2%). Overall, 303 patients (73.7%) received BCG, and 108 patients (26.3%) underwent iRC. The median (interquartile range) follow\u2010up was 53\u2009(32\u201396) months. Patients with E\/M LP invasion were significantly more likely to undergo iRC (34% vs. 19%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003). Patients with E\/M LP invasion showed poorer MFS and CSS compared to those with F\/S LP invasion when treated with BCG but not when treated with iRC. Among BCG\u2010treated patients, progression occurred in 41 patients and E\/M LP invasion was independently associated with progression after BCG (hazard ratio 5.3, 95% confidence interval [CI] 2.2\u201313.1;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). T1 substaging was not associated with upstaging at RC (odds ratio 3.15, 95% CI 0.82\u201312.12;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.095).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Extensive\/multifocal LP invasion was associated with poor PFS, MFS and CSS in patients treated with BCG. T1 substaging provides valuable prognostic information and should be reported in pathology reports.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16293","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:07:05Z","timestamp":1708387625000},"page":"733-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Influence of lamina propria invasion extension on T1 high\u2010grade non\u2010muscle\u2010invasive bladder cancer in patients undergoing BCG or radical cystectomy"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7011-0537","authenticated-orcid":false,"given":"Roberto","family":"Contieri","sequence":"first","affiliation":[{"name":"Department of Urology University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele, Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-4043","authenticated-orcid":false,"given":"Wei Shen","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Grajales","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Hensley","sequence":"additional","affiliation":[{"name":"Department of Urology University of Kentucky College of Medicine  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4532-7763","authenticated-orcid":false,"given":"Kelly","family":"Bree","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Nogueras\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neema","family":"Navai","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas MD Anderson Cancer Center  Houston Texas 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