{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:30:21Z","timestamp":1788348621068,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore how the use of the ProPep\u00ae Nerve Monitoring System (ProPep Surgical, Austin, TX, USA) for intraoperative specific sparing of the pudendal nerve fibres influences postoperative functional outcomes after unilateral nerve\u2010sparing (UNS) or non\u2010nerve\u2010sparing (NNS) robot\u2010assisted radical prostatectomy (RARP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We randomised 100 men undergoing UNS or NNS RARP to ProPep nerve monitoring during RARP (intervention) or standard of care RARP (control). Functional outcomes were assessed at 3, 6, and 12\u2009months using the International Consultation on Incontinence Questionnaire Short Form (ICIQ\u2010SF), the International Prostate Symptom Score, the Danish Prostate Symptom Score, the International Index of Erectile Function, the Erection Hardness Scale, and 24\u2010h pad tests. The primary outcome was the difference in ICIQ\u2010SF score between the groups at 12\u2009months. Secondary outcomes included differences in the remaining outcome measures and continence rates at all time points. Continence was defined as the use of no pads and the answer \u2018Never\u2019 to the question: \u2018How often do you experience urinary incontinence?\u2019 or a urine loss of &lt;8\u2009g on the 24\u2010h pad test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 82 patients were included in the per\u2010protocol analysis at 12\u2009months with 41 in each group. At 12\u2009months the mean ICIQ\u2010SF scores were 5.37\u2009(95% confidence interval [CI] 3.71\u20137.03) and 5.66\u2009(95% CI 4.05\u20137.27) for the intervention and control groups, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.8). There were no statistically significant differences in any of the remaining outcomes. However, the continence rate was higher in the intervention group at 6\u2009months (63% vs 44%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.09).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intraoperative nerve monitoring did not result in better functional outcomes following UNS or NNS RARP. Larger studies are needed to explore if ProPep can reduce the time to continence after RARP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16295","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T04:15:37Z","timestamp":1707797737000},"page":"742-751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Can nerve monitoring during radical prostatectomy improve functional outcomes? A randomised trial"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6493-1961","authenticated-orcid":false,"given":"Alexander B.","family":"Nols\u00f8e","sequence":"first","affiliation":[{"name":"Department of Urology Copenhagen University Hospital, Herlev and Gentofte Hospital  Herlev Denmark"},{"name":"Institute for Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4762-039X","authenticated-orcid":false,"given":"Peter Busch","family":"\u00d8stergren","sequence":"additional","affiliation":[{"name":"Department of Urology Copenhagen University Hospital, Herlev and Gentofte Hospital  Herlev Denmark"},{"name":"Institute for Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Urology Copenhagen University Hospital, Herlev and Gentofte Hospital  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Fuglesang S.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Urology Copenhagen University Hospital, Herlev and Gentofte Hospital  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Henrik","family":"Bruun","sequence":"additional","affiliation":[{"name":"Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"S\u00f8nksen","sequence":"additional","affiliation":[{"name":"Department of Urology Copenhagen University Hospital, Herlev and Gentofte Hospital  Herlev Denmark"},{"name":"Institute for Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel","family":"Fode","sequence":"additional","affiliation":[{"name":"Department of Urology Copenhagen University Hospital, Herlev and Gentofte Hospital  Herlev Denmark"},{"name":"Institute for Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1807801"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2214122"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.05.045"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2018.12.004"},{"key":"e_1_2_10_6_1","article-title":"Laparoscopic and robotic\u2010assisted versus open radical prostatectomy for the treatment of localised prostate 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